GABBR1

Gene Symbol GABBR1
Entrez Gene 2550
Alt Symbol GABABR1, GABBR1-3, GB1, GPRC3A, dJ271M21.1.1, dJ271M21.1.2
Species Human
Gene Type protein-coding
Description gamma-aminobutyric acid (GABA) B receptor, 1
Other Description GABA-BR1|GABAB, subunit 1c|gamma-aminobutyric acid type B receptor subunit 1|seven transmembrane helix receptor
Swissprots Q5SUJ8 Q5STL4 Q9UQQ0 Q86W60 Q5SUL3 O95375 Q9UBS5 O95975 O96022 O95468 B0UXY7 Q71SG6
Accessions BAC05730 CAA09031 CAA21453 CAA21454 CAI79356 EAX03205 EAX03206 EAX03207 EAX03208 EAX03209 EAX03210 EAX03211 EAX03212 Q9UBS5 AB208790 BAD92027 AF099148 AAC98508 AF301005 AAG23962 AJ012185 CAA09939 AJ012186 CAA09940 AJ012187 CAA09941 AJ012288 CAA09980 AJ225028 CAA12359 AJ225029 CAA12360 AK223619 BAD97339 AK290191 BAF82880 AK312308 BAG35233 BC023336 BC041332 AAH41332 BC042598 AAH42598 BC050532 AAH50532 DA112662 DA400111 Y11044 XM_005248982 XP_005249039 XM_005272785 XP_005272842 XM_005274841 XP_005274898 XM_005274931 XP_005274988 XM_005275088 XP_005275145 XM_005275227 XP_005275284 XM_005275363 XP_005275420 XM_006715047 XP_006715110 XM_006725030 XP_006725093 XM_006725477 XP_006725540 XM_006725691 XP_006725754 XM_006725807 XP_006725870 XM_006725901 XP_006725964 XM_006725988 XP_006726051 XM_011514453 XP_011512755 XM_011514454 XP_011512756 XM_011514455 XP_011512757 XM_011514456 XP_011512758 XM_011546282 XP_011544584 XM_011546283 XP_011544585 XM_011546284 XP_011544586 XM_011547197 XP_011545499 XM_011547198 XP_011545500 XM_011547199 XP_011545501 XM_011547200 XP_011545502 XM_011547611 XP_011545913 XM_011547612 XP_011545914 XM_011547613 XP_011545915 XM_011547614 XP_011545916 XM_011547848 XP_011546150 XM_011547849 XP_011546151 XM_011548017 XP_011546319 XM_011548018 XP_011546320 XM_011548019 XP_011546321 XM_011548020 XP_011546322 XM_011548206 XP_011546508 XM_011548207 XP_011546509 XM_011548208 XP_011546510 XM_011548209 XP_011546511 XR_241884 XR_246960 XR_247352 XR_247386 XR_247400 XR_430672 XR_430972 NM_001470 NP_001461 NM_021903 NP_068703 NM_021904 NP_068704 NM_021905
Function Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conduct
Subcellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. {ECO:0000250}.
Tissue Specificity Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. {ECO:0000269|PubMed:9844003}.
Top Pathways GABAergic synapse, Morphine addiction, Estrogen signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction

Human GABA B Receptor 1 full length protein - ab152406 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE analysis of ab152406 stained with Coomassie Blue.

Human GABA B Receptor 1 protein fragment - ab112287 from Abcam

Category Protein
Source Wheat germ
Species Human
ab112287 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

GABBR1 / GABA B Receptor 1 Antibody Blocking Peptide - LS-E29055 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

GABBR1 / GABA B Receptor 1 Antibody Blocking Peptide - LS-E29056 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

GABBR1 / GABA B Receptor 1 Antibody Blocking Peptide - LS-E26947 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human GABA-B R1 Protein - H00002550-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human

Recombinant Human GABA-B R1 Protein - H00002550-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human GABA-B R1 Protein - H00002550-G01 from Novus Biologicals

Category Protein
Prices $569.00
Sizes 10 µg
Source Wheat Germ
Species Human

GABA-B R1 Peptide - NBP1-19356PEP from Novus Biologicals

Category Peptide
Prices $229.00
Sizes 100 µg

GABBR1-Antibody-Center-Blocking-peptide - BP11234c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

GABBR1 Blocking Peptide - abx062647 from Abbexa

Category Peptide
Species Human, Mouse, Rat, Bovine, Pig

GABBR1 - H00002550-G01 from Acris Antibodies

Category Protein
Prices $550.00
Sizes 10 µg
Species Human

GABBR1 - H00002550-P01 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Species Human

GABBR1 - H00002550-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

GABBR1 - H00002550-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

GABBR1 fusion protein - ag7113 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

GABBR1 fusion protein - ag4838 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human GABBR1 - GABBR1-28091TH from Creative Biomart

Category Protein
Source Wheat germ
Species Human

GABBR1 Blocking Peptide - CBP1453 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat, Bovine, Pig

GABBR1 Blocking Peptide - CBP3949 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Rat, Bovine, Monkey

GABAB R1 (I902) Peptide - BS1133P from Bioworld Technology

Category Peptide
Prices $158.00
Sizes 100 µl

GABAB R1 (P931) Peptide - BS2717P from Bioworld Technology

Category Peptide
Prices $158.00
Sizes 100 µl

Recombinant Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) - RPC934Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

Recombinant Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) - RPC934Hu01 from Cloud-clone

Category Protein
Source E.coli
Species Human

GABA-B R1 Recombinant Protein Antigen - NBP2-14033PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human
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