| Gene Symbol | Ifne |
|---|---|
| Entrez Gene | 230405 |
| Alt Symbol | Ifn-tau-1, Ifne1, Ifnt1, Infe1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | interferon epsilon |
| Other Description | IFN-epsilon|interferon epsilon 1|interferon epsilon-1|interferon tau-1 |
| Swissprots | Q80ZF2 |
| Accessions | CAA38558 Q80ZF2 AY190044 AAO38685 BC104376 AAI04377 BC104377 AAI04378 NM_177348 NP_796322 |
| Function | Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral, including HSV-2, and bacterial, including Chlamydia muridarum, genital infections. {ECO:0000269|PubMed:23449591}. |
| Subcellular Location | Secreted {ECO:0000305}. |
| Tissue Specificity | Expressed at very high levels in uterus and, at much lower levels, in ovary and cervix. Very low levels, if any, in other organs. In the endometrium, expressed in the luminal and glandular epithelial cells (at protein level). {ECO:0000269|PubMed:15233997, ECO:0000269|PubMed:23449591}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, RIG-I-like receptor signaling pathway |