BCL6

Gene Symbol	BCL6
Entrez Gene	604
Alt Symbol	BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
Species	Human
Gene Type	protein-coding
Description	B-cell CLL/lymphoma 6
Other Description	B-cell lymphoma 5 protein|B-cell lymphoma 6 protein|B-cell lymphoma 6 protein transcript|BCL-5|BCL-6|cys-his2 zinc finger transcription factor|lymphoma-associated zinc finger gene on chromosome 3|protein LAZ-3|zinc finger and BTB domain-containing protein 27|zinc finger protein 51|zinc finger transcription factor BCL6S
Swissprots	P41182 D3DNV5 B8PSA7 A7E241
Accessions	AAA61320 EAW78140 EAW78141 P41182 AI624861 AK090890 AK304325 BAG65174 AK308162 AW337942 AW470156 BC142705 AAI42706 BC146796 BC150184 AAI50185 BX649185 CAE46203 CN401512 DB025893 DB079847 EU139066 ABX45135 EU883531 ACG60659 S67779 U00115 AAC50054 Z21943 CAA79937 XM_005247694 XP_005247751 XM_011513062 XP_011511364 NM_001130845 NP_001124317 NM_001134738 NP_001128210 NM_001706 NP_001697 NM_138931
Function	Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6- binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physio
Subcellular Location	Nucleus {ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356}.
Tissue Specificity	Expressed in germinal center T- and B-cells and in primary immature dendritic cells. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:16455075, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:9649500}.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

B-cell lymphoma 6 protein (BCL6), Human, ELISA Kit - E01B0770 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Bcl-6 Colorimetric Cell-Based ELISA Kit - CB5069 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

B cell lymphoma 6 protein (BCL6), ELISA Kit - MBS7203268 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

B-cell CLL/lymphoma 6, ELISA Kit - MBS705459 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human Bcl6 is typically less than 4.67 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 18.75 pg/ml -1200 pg/ml.

B-cell lymphoma 6 protein (BCL6), ELISA Kit - MBS7232260 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell lymphoma 6 protein (BCL6), ELISA Kit - MBS7251011 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell lymphoma 6 protein (BCL6), ELISA Kit - MBS7211600 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell lymphoma 6 protein (BCL6), ELISA Kit - MBS7213158 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell lymphoma 6 protein (BCL6), ELISA Kit - MBS7221369 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell lymphoma 6 protein (BCL6), ELISA Kit - MBS7211903 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell lymphoma 6 protein (BCL6), ELISA Kit - MBS7209365 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell lymphoma 6 protein (BCL6), ELISA Kit - MBS7209642 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell lymphoma 6 protein (BCL6), ELISA Kit - MBS7222975 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell lymphoma 6 protein (BCL6), ELISA Kit - MBS7212740 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

B-cell lymphoma 6 protein (BCL6), ELISA Kit - MBS7230180 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human B-cell leukemia/lymphoma 6,Bcl6 ELISA Kit - CSB-E14975h from Cusabio Category ELISA Kit Sensitivity 4.68 pg/ml. Range 18.75 pg/ml-1200 pg/ml

Bcl-6 ELISA Kit - DEIA-XYA278 from Creative Diagnostics Category ELISA Kit

Human BCL6 ELISA Kit - E004319 from Biobool Category ELISA Kit Sensitivity 1.0 pg/mL.

anti-BCL6 antibody [BCL6/1527] - ARG57518 from Arigo Biolaboratories Category ELISA Kit

anti-BCL6 antibody [SP155] - ARG52561 from Arigo Biolaboratories Category ELISA Kit

anti-BCL6 antibody - ARG52559 from Arigo Biolaboratories Category ELISA Kit

anti-BCL6 antibody [SP155] (Ready-to-Use) - ARG52562 from Arigo Biolaboratories Category ELISA Kit

anti-BCL6 antibody (Ready-to-Use) - ARG52560 from Arigo Biolaboratories Category ELISA Kit

BCL6 ELISA Kit (Human) (OKCA01120) - OKCA01120 from Aviva Systems Biology Category ELISA Kit Prices $665.00 Sizes 96 wells Sensitivity 4.68 pg/mL Range 18.75 - 1,200 pg/mL

Bcl-6 Colorimetric Cell-Based ELISA Kit - EKA50058 from Biomatik Category ELISA Kit Prices $399.00 Sizes 96 tests Sensitivity At least 5000 cells/well Range Qualitative

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