BCL6

Gene Symbol	BCL6
Entrez Gene	604
Alt Symbol	BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
Species	Human
Gene Type	protein-coding
Description	B-cell CLL/lymphoma 6
Other Description	B-cell lymphoma 5 protein|B-cell lymphoma 6 protein|B-cell lymphoma 6 protein transcript|BCL-5|BCL-6|cys-his2 zinc finger transcription factor|lymphoma-associated zinc finger gene on chromosome 3|protein LAZ-3|zinc finger and BTB domain-containing protein 27|zinc finger protein 51|zinc finger transcription factor BCL6S
Swissprots	P41182 D3DNV5 B8PSA7 A7E241
Accessions	AAA61320 EAW78140 EAW78141 P41182 AI624861 AK090890 AK304325 BAG65174 AK308162 AW337942 AW470156 BC142705 AAI42706 BC146796 BC150184 AAI50185 BX649185 CAE46203 CN401512 DB025893 DB079847 EU139066 ABX45135 EU883531 ACG60659 S67779 U00115 AAC50054 Z21943 CAA79937 XM_005247694 XP_005247751 XM_011513062 XP_011511364 NM_001130845 NP_001124317 NM_001134738 NP_001128210 NM_001706 NP_001697 NM_138931
Function	Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6- binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physio
Subcellular Location	Nucleus {ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356}.
Tissue Specificity	Expressed in germinal center T- and B-cells and in primary immature dendritic cells. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:16455075, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:9649500}.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Bcl6 full length protein - ab39476 from Abcam Category Protein Prices $342.00 Sizes 10 µg Source E. coli Species Human

Human Bcl6 peptide - ab97495 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Recombinant Human Bcl-6 Protein - H00000604-Q01 from Novus Biologicals Category Protein Prices $315.00, $460.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Bcl-6 Protein - P4858 from Novus Biologicals Category Protein Prices $799.00 Sizes 10 µg Source E. coli Species Human

BCL6-Antibody-C-term-Blocking-peptide - BP13061b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Bcl-6-Antibody-C-term-Blocking-Peptide - BP7372b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Bcl 6 Protein (OPPA01366) - OPPA01366 from Aviva Systems Biology Category Protein Prices $315.00 Sizes 2 µg Source E. Coli

Human Bcl 6 protein - orb80959 from Biorbyt Category Protein Prices $366.00, $400.00, $612.00 Sizes 5 μg, 2 μg, 10 μg Species Human

Bcl 6 Blocking Peptide - 33R-10485 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

BCL6 Blocking Peptide - 33R-10747 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

BCL6 Blocking Peptide - abx161304 from Abbexa Category Peptide Species Human, Mouse, Rat, Dog

BCL6 Blocking Peptide - abx161029 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Dog, Pig

Bcl-6 - H00000604-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Bcl-6 - H00000604-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Bcl-6 - P4858 from Acris Antibodies Category Protein Prices $750.00 Sizes 10 µg Species Human

Bcl-6 (Center) Control Peptide - AP55495CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

BCL6 Peptide - 6985P from ProSci Category Peptide Species Human

BCL6 fusion protein - Ag15519 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

BCL6 fusion protein - Ag15675 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Bcl 6 Human - PRPS-467 from NeoScientific Category Protein Prices $351.00, $637.00 Sizes 5 µg, 10 µg Source Escherichia Coli. Species Human

Recombinant Human B-cell lymphoma 6 protein - BP001831-PRO-460 from Syd Labs Category Protein Prices $175.00, $270.00, $490.00 Sizes 2 µg, 5 µg, 10 µg Source E. coli-derived. Species Human

Bcl-6 - GWB-192A3E from Genway Biotech Category Protein Prices $438.00 Sizes 10 µg

Recombinant Human BCL6 - BCL6-26735TH from Creative Biomart Category Protein Source E. coli

Recombinant Human BCL6, Trx & His tagged - BCL6-6873H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human BCL6, GST-tagged - BCL6-10185H from Creative Biomart Category Protein Source E.coli Species Human

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