| Gene Symbol |
HSD17B6
|
| Entrez Gene |
533086
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
hydroxysteroid (17-beta) dehydrogenase 6
|
| Other Description |
17-beta-HSD 6|17-beta-HSD6|17-beta-hydroxysteroid dehydrogenase type 6|3-alpha->beta-HSE|3-alpha->beta-hydroxysteroid epimerase|hydroxysteroid (17-beta) dehydrogenase 6 homolog|hydroxysteroid 17-beta dehydrogenase 6|oxidative 3-alpha hydroxysteroid dehydrogenase
|
| Swissprots |
Q3T001
|
| Accessions |
DAA29789 Q3T001 BC102626 AAI02627 NM_001035395 NP_001030472
|
| Function |
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha- androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}.
|
| Top Pathways |
Steroid hormone biosynthesis, Retinol metabolism
|