| Gene Symbol | HSD17B6 |
|---|---|
| Entrez Gene | 533086 |
| Alt Symbol | - |
| Species | Bovine |
| Gene Type | protein-coding |
| Description | hydroxysteroid (17-beta) dehydrogenase 6 |
| Other Description | 17-beta-HSD 6|17-beta-HSD6|17-beta-hydroxysteroid dehydrogenase type 6|3-alpha->beta-HSE|3-alpha->beta-hydroxysteroid epimerase|hydroxysteroid (17-beta) dehydrogenase 6 homolog|hydroxysteroid 17-beta dehydrogenase 6|oxidative 3-alpha hydroxysteroid dehydrogenase |
| Swissprots | Q3T001 |
| Accessions | DAA29789 Q3T001 BC102626 AAI02627 NM_001035395 NP_001030472 |
| Function | NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha- androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids (By similarity). {ECO:0000250}. |
| Subcellular Location | Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}. |
| Top Pathways | Steroid hormone biosynthesis, Retinol metabolism |
Recombinant Bovine 17-beta-hydroxysteroid dehydrogenase type 6(HSD17B6) - CSB-YP660976BO CSB-EP660976BO CSB-BP660976BO CSB-MP660976BO from Cusabio
|
||||||||||
17-beta-hydroxysteroid dehydrogenase type 6 (HSD17B6), Recombinant Protein - MBS1419275 from MyBioSource
|