CCL5

Gene Symbol	CCL5
Entrez Gene	6352
Alt Symbol	D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP
Species	Human
Gene Type	protein-coding
Description	chemokine (C-C motif) ligand 5
Other Description	C-C motif chemokine 5|T-cell specific protein p288|beta-chemokine RANTES|eosinophil chemotactic cytokine|regulated upon activation, normally T-expressed, and presumably secreted|small inducible cytokine subfamily A (Cys-Cys), member 5
Swissprots	Q4ZGJ1 Q9UBG2 O43646 Q9UC99 P13501 Q9NYA2 Q0QVW8
Accessions	AAC63331 AAD14942 AAY22177 ACW84342 BAA76937 BAA76938 BAA76939 CAY55955 EAW80120 P13501 AA443491 AA486131 AF043341 AAC03541 AF266753 AAF73070 AK312212 BAG35145 AW769950 BC008600 AAH08600 BG272739 CB111656 CD695497 CR980938 DQ230537 ABB69929 DQ891490 ABM82416 DQ894681 ABM85607 GD136908 HY265548 M21121 AAA36725 NM_001278736 NP_001265665 NM_002985 NP_002976
Function	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1- infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1- 68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobiliz
Subcellular Location	Secreted.
Tissue Specificity	T-cell and macrophage specific.
Top Pathways	TNF signaling pathway, Cytokine-cytokine receptor interaction, Herpes simplex infection, Influenza A, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RANTES full length protein - ab168002 from Abcam Category Protein Prices $883.00 Sizes 100 µg Source E. coli Species Human

Active human RANTES full length protein - ab192136 from Abcam Category Protein Prices $192.00 Sizes 20 µg Source E. coli Species Human

Active pig RANTES protein fragment - ab87461 from Abcam Category Protein Prices $239.00 Sizes 25 µg Source Saccharomyces cerevisiae Species Pig

Active RANTES full length protein - ab9680 from Abcam Category Protein Prices $257.00 Sizes 20 µg Source E. coli

Active RANTES full length protein - ab9916 from Abcam Category Protein Prices $257.00 Sizes 20 µg Source E. coli

Active RANTES full length protein - ab9784 from Abcam Category Protein Prices $110.00, $239.00 Sizes 5 µg, 20 µg Source E. coli

Active rat RANTES full length protein - ab78608 from Abcam Category Protein Prices $257.00 Sizes 5 µg Source E. coli Species Rat

Active rat RANTES full length protein - ab111466 from Abcam Category Protein Prices $939.00 Sizes 100 µg Source E. coli Species Rat

Cow RANTES full length protein - ab87393 from Abcam Category Protein Prices $235.00 Sizes 25 µg Source Saccharomyces cerevisiae Species Bovine

Dog RANTES full length protein - ab169722 from Abcam Category Protein Prices $235.00 Sizes 25 µg Source Yeast Species Dog

Guinea pig RANTES full length protein - ab128522 from Abcam Category Protein Prices $235.00 Sizes 25 µg Source Yeast Species Guinea Pig

Human RANTES full length protein - ab194044 from Abcam Category Protein Source Mammalian Species Human

Human RANTES full length protein - ab175166 from Abcam Category Protein Source Synthetic Species Human

Human RANTES full length protein - ab176052 from Abcam Category Protein Source Synthetic Species Human

Human RANTES full length protein - ab87758 from Abcam Category Protein Source E. coli Species Human

RANTES full length protein - ab88199 from Abcam Category Protein Source Saccharomyces cerevisiae

RANTES peptide - ab110205 from Abcam Category Peptide

Recombinant Human CCL5/RANTES Protein - NBP2-35235 from Novus Biologicals Category Protein Prices $69.00, $169.00, $2,669.00 Sizes 5 µg, 20 µg, 1 mg Source E. coli Species Human

CCL5/RANTES Protein - NBP1-43158 from Novus Biologicals Category Protein Prices $229.00 Sizes 5 µg

CCL5/RANTES Recombinant Protein - H00006352-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CCL5/RANTES Protein - NBP1-30213 from Novus Biologicals Category Protein Prices $499.00 Sizes 100 µg Species Human

CCL5/RANTES Protein - NBP1-42878 from Novus Biologicals Category Protein Prices $699.00 Sizes 100 µg

CCL5/RANTES Recombinant Protein - P3664 from Novus Biologicals Category Protein Prices $369.00 Sizes 20 µg Species Human

CCL5/RANTES Protein - NBP1-99253 from Novus Biologicals Category Protein Prices $299.00 Sizes 20 µg Species Human

CCL5/RANTES Protein - NBP1-43155 from Novus Biologicals Category Protein Prices $229.00 Sizes 5 µg

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