ITGA6

Gene Symbol	ITGA6
Entrez Gene	3655
Alt Symbol	CD49f, ITGA6B, VLA-6
Species	Human
Gene Type	protein-coding
Description	integrin, alpha 6
Other Description	CD49 antigen-like family member F|integrin alpha-6|integrin alpha6B
Swissprots	Q0MRC7 Q14646 Q53RX7 C4AM96 P23229 G5E9H1 B4DG69 Q86VL6 Q9UCT1 Q08443 Q9UN03 Q59HB7 B2RMU9 Q16508 B4DKB8
Accessions	AAB24829 AAD48469 AAX93133 CCF76946 CCF76947 EAX11175 EAX11176 EAX11177 P23229 AB208842 BAD92079 AF401206 AK294436 BAG57680 AK296496 BAG59130 AK307777 AK311695 BC007002 BC050585 AAH50585 BC136455 AAI36456 BC136456 AAI36457 BX537483 DA760250 DQ858220 ABH11650 EF491782 EF491790 EF491812 S66196 AAB20354 S66213 AAB20355 X53586 CAA37655 X59512 CAA42099 XM_006712510 XP_006712573 XM_006712511 XP_006712574 NM_000210 NP_000201 NM_001079818 NP_001073286
Function	Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. {ECO:0000269|PubMed:17303120}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:22314500}; Single-pass type I membrane protein {ECO:0000269|PubMed:22314500}. Cell membrane {ECO:0000269|PubMed:22314500}; Lipid-anchor {ECO:0000269|PubMed:22314500}.
Tissue Specificity	Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). {ECO:0000269|PubMed:7681434}.
Top Pathways	PI3K-Akt signaling pathway, Focal adhesion, Toxoplasmosis, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Integrin alpha 6 protein fragment - ab158769 from Abcam Category Protein Source Wheat germ Species Human

ITGA6/Integrin Alpha 6/CD49f Antibody Blocking Peptide - LS-E7071 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITGA6/Integrin Alpha 6/CD49f Antibody Blocking Peptide - LS-E29476 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ITGA6/Integrin Alpha 6/CD49f Antibody Blocking Peptide - LS-E29477 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ITGA6/Integrin Alpha 6/CD49f Antibody Blocking Peptide - LS-E29478 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ITGA6/Integrin Alpha 6/CD49f Antibody Blocking Peptide - LS-E29480 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ITGA6/Integrin Alpha 6/CD49f Antibody Blocking Peptide - LS-E10028 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Integrin alpha 6/CD49f Protein - H00003655-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Integrin alpha 6/CD49f Protein - H00003655-G01 from Novus Biologicals Category Protein Prices $519.00 Sizes 2 µg Source Wheat Germ Species Human

ITGA6-Antibody-isoform-2-S1064-Blocking-Peptide - BP2753a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-ITGA6-iso2S1064-Antibody-Blocking-peptide - BP3687a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

CD49f-Antibody-C-term-Blocking-Peptide - BP9255b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Integrin alpha 6 (X1) beta 4, CF - 5497-A6-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Recombinant Mouse Integrin alpha 6 beta 4, CF - 8067-A6-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Human ITGA6 flag His tag protein - orb84478 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source Human Species Human

ITGA6 peptide - orb217469 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

CD49f / ITGA6 - H00003655-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD49f / ITGA6 - H00003655-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD49f / ITGA6 - H00003655-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Integrin alpha-6 fusion protein - Ag16335 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Integrin alpha-6 fusion protein - ag17991 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

ITGA6 fusion protein - ag0527 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human FGF1, Met-tagged - FGF1-619H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human FKBP1A, Met&His-tagged - FKBP1A-621H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human GAS6, His-tagged - GAS6-623H from Creative Biomart Category Protein Source NSO cells Species Human

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