ITGA6

Gene Symbol ITGA6
Entrez Gene 3655
Alt Symbol CD49f, ITGA6B, VLA-6
Species Human
Gene Type protein-coding
Description integrin, alpha 6
Other Description CD49 antigen-like family member F|integrin alpha-6|integrin alpha6B
Swissprots Q0MRC7 Q14646 Q53RX7 C4AM96 P23229 G5E9H1 B4DG69 Q86VL6 Q9UCT1 Q08443 Q9UN03 Q59HB7 B2RMU9 Q16508 B4DKB8
Accessions AAB24829 AAD48469 AAX93133 CCF76946 CCF76947 EAX11175 EAX11176 EAX11177 P23229 AB208842 BAD92079 AF401206 AK294436 BAG57680 AK296496 BAG59130 AK307777 AK311695 BC007002 BC050585 AAH50585 BC136455 AAI36456 BC136456 AAI36457 BX537483 DA760250 DQ858220 ABH11650 EF491782 EF491790 EF491812 S66196 AAB20354 S66213 AAB20355 X53586 CAA37655 X59512 CAA42099 XM_006712510 XP_006712573 XM_006712511 XP_006712574 NM_000210 NP_000201 NM_001079818 NP_001073286
Function Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. {ECO:0000269|PubMed:17303120}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:22314500}; Single-pass type I membrane protein {ECO:0000269|PubMed:22314500}. Cell membrane {ECO:0000269|PubMed:22314500}; Lipid-anchor {ECO:0000269|PubMed:22314500}.
Tissue Specificity Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). {ECO:0000269|PubMed:7681434}.
Top Pathways PI3K-Akt signaling pathway, Focal adhesion, Toxoplasmosis, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Integrin α6 CRISPR/Cas9 KO Plasmid (h) - sc-400380 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α6 HDR Plasmid (h) - sc-400380-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α6 Double Nickase Plasmid (h) - sc-400380-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α6 Double Nickase Plasmid (h2) - sc-400380-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α6 CRISPR Activation Plasmid (h) - sc-400380-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α6 CRISPR Activation Plasmid (h2) - sc-400380-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α6 Lentiviral Activation Particles (h) - sc-400380-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α6 Lentiviral Activation Particles (h2) - sc-400380-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α6 siRNA (h) - sc-43129 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Integrin α6 shRNA Plasmid (h) - sc-43129-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Integrin α6 shRNA (h) Lentiviral Particles - sc-43129-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Integrin alpha 6/CD49f RNAi - H00003655-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU088861 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1896 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1896 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11368 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11368

ITGA6 siRNA (Human) - CRH2449 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ITGA6 - MBS8202686 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Itga6 (NM_000210.2) - SHH321221 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ITGA6(NM_000210.2) - SHL181542 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ITGA6(NM_001079818.1) - SHL181578 from Creative biogene

Category siRNA
Species Reactivities Human

Human ITGA6 siRNA - orb262951 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ITGA6 shRNA Plasmid (Human) - CHH2449 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ITGA6 miRNA 3'UTR clone - MiUTR1H-05023 from Creative biogene

Species Reactivities Human

ITGA6 miRNA 3'UTR clone - MiUTR1H-05024 from Creative biogene

Species Reactivities Human
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