DIAPH1

Gene Symbol	DIAPH1
Entrez Gene	1729
Alt Symbol	DFNA1, DIA1, DRF1, LFHL1, hDIA1
Species	Human
Gene Type	protein-coding
Description	diaphanous-related formin 1
Other Description	diaphanous homolog 1|diaphanous-related formin-1|protein diaphanous homolog 1
Swissprots	Q59FH8 B7ZKW2 O60610 Q17RN4 A6NF18 Q9UC76 E9PEZ2
Accessions	EAW61919 EAW61920 O60610 AB209482 BAD92719 AF051782 AAC05373 AK023345 BAB14533 AK057994 AK094264 AK301195 BAG62775 AK304291 BAG65149 AK307822 AL050086 AY007129 AY360322 AAQ64023 AY363395 AAQ63049 BC007411 AAH07411 BC117257 AAI17258 BC143413 AAI43414 BC143414 BQ945734 BT007318 AAP35982 DA593734 DQ067452 AAZ23039 DQ067453 AAZ23040 XM_005268384 XP_005268441 XM_011537572 XP_011535874 XM_011537573 XP_011535875 NM_001079812 NP_001073280 NM_005219 NP_005210
Function	Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membr
Subcellular Location	Cell membrane. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Note=Membrane ruffles, especially at the tip of ruffles, of motile cells.
Tissue Specificity	Expressed in brain, heart, placenta, lung, kidney, pancreas, liver, skeletal muscle and cochlea.
Top Pathways	Focal adhesion, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DIAPH1 ELISA Kit (Sandwich ELISA) - LS-F7427 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.051 ng/ml Range 0.156-10 ng/ml

Human Diaphanous Homolog 1 ELISA Kit - abx151314 from Abbexa Category ELISA Kit Sensitivity 0.051 ng/ml Range 0.156 ng/ml - 10 ng/ml

Diaphanous Homolog 1 (DIAPH1), Human, ELISA Kit - SEJ265Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.051ng/mL Range 0.156-10ng/mL

Diaphanous Homolog 1, ELISA Kit - MBS104973 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Diaphanous Homolog 1, ELISA Kit - MBS047707 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Diaphanous Homolog 1, ELISA Kit - MBS063333 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Diaphanous Homolog 1, ELISA Kit - MBS105603 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Diaphanous Homolog 1, ELISA Kit - MBS090249 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Diaphanous Homolog 1, ELISA Kit - MBS097423 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Diaphanous Homolog 1, ELISA Kit - MBS100571 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Diaphanous Homolog 1 (DIAPH1), ELISA Kit - MBS2019301 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.051ng/mL. Range 0.156-10ng/mL

diaphanous homolog 1 (Drosophila) , ELISA Kit - MBS9318172 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Diaphanous Homolog 1 (DIAPH1) - SEJ265Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.051ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Diaphanous Homolog 1 (DIAPH1) - SEJ265Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.051ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Diaphanous Homolog 1 (DIAPH1) ELISA Kit - EKU03723 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.051 ng/mL Range 0.156-10 ng/mL

Diaphanous Homolog 1 (DIAPH1), Human, ELISA Kit - DL-DIAPH1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human DIAPH1 ELISA Kit - abx571071 from Abbexa Category ELISA Kit Sensitivity 0.051 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human DIAPH1 ELISA Kit - E011874 from Biobool Category ELISA Kit Sensitivity Typically less than 0.051ng/mL.

DIAPH1 ELISA Kit (Human) (OKDD00229) - OKDD00229 from Aviva Systems Biology Category ELISA Kit Prices $580.00 Sizes 96 wells Sensitivity < 0.051 ng/mL Range 0.156-10 ng/mL

anti-DIAPH1 antibody - ARG55315 from Arigo Biolaboratories Category ELISA Kit

anti-DIAPH1 antibody - ARG65142 from Arigo Biolaboratories Category ELISA Kit

Human Protein diaphanous homolog 1 (DIAPH1) ELISA Kit - AE61271HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.051 ng/mL Range 0.156-10 ng/mL

Diaphanous Homolog 1 (DIAPH1), ELISA Kit - MBS453302 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.051ng/mL Range 0.156-10ng/mL

Diaphanous Homolog 1 (DIAPH1), ELISA Kit - MBS9380678 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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