CPLX2

Gene Symbol CPLX2
Entrez Gene 10814
Alt Symbol 921-L, CPX-2, CPX2, Hfb1
Species Human
Gene Type protein-coding
Description complexin 2
Other Description CPX II|complexin II|complexin-2|synaphin 1|synaphin-1
Swissprots Q52M15 B2RAG2 Q6PUV4
Accessions EAW61366 EAW61367 Q6PUV4 AK055043 AK094266 AK124837 AK126590 AK293819 BAG57224 AK314177 BAG36859 AL512758 AL707430 AY576870 AAS93622 BC039560 BC052974 BC065485 BC093706 AAH93706 BC112287 AAI12288 BI197868 BN000499 CAG26663 BN000500 CAG26664 U35100 AAC50229 Y15167 XM_005265798 XP_005265855 XM_005265799 XP_005265856 XM_011534419 XP_011532721 NM_001008220 NP_001008221 NM_006650 NP_006641
Function Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.
Tissue Specificity Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia. {ECO:0000269|PubMed:11483314, ECO:0000269|PubMed:11576753, ECO:0000269|PubMed:15906159, ECO:0000269|PubMed:16162394, ECO:0000269|PubMed:9853440}.
Top Pathways Synaptic vesicle cycle

Complexin-2 CRISPR/Cas9 KO Plasmid (h) - sc-406799 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-2 HDR Plasmid (h) - sc-406799-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-2 Double Nickase Plasmid (h) - sc-406799-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-2 Double Nickase Plasmid (h2) - sc-406799-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-2 CRISPR Activation Plasmid (h) - sc-406799-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-2 CRISPR Activation Plasmid (h2) - sc-406799-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-2 Lentiviral Activation Particles (h) - sc-406799-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-2 Lentiviral Activation Particles (h2) - sc-406799-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-2 siRNA (h) - sc-41925 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Complexin-2 shRNA Plasmid (h) - sc-41925-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Complexin-2 shRNA (h) Lentiviral Particles - sc-41925-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU116511 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6504 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6504 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CPLX2 siRNA (Human) - CRH7372 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CPLX2 - MBS8220039 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CPLX2 (NM_006650.3) - SHH268677 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CPLX2(NM_001008220.1) - SHG196147 from Creative biogene

Category siRNA
Species Reactivities Human

Complexin-2 CRISPR/Cas9 KO Plasmid (h2) - sc-406799-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Complexin-2 HDR Plasmid (h2) - sc-406799-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CPLX2 shRNA Plasmid (Human) - CHH7372 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CPLX2 miRNA 3'UTR clone - MiUTR1H-02391 from Creative biogene

Species Reactivities Human
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