CPLX2

Gene Symbol CPLX2
Entrez Gene 10814
Alt Symbol 921-L, CPX-2, CPX2, Hfb1
Species Human
Gene Type protein-coding
Description complexin 2
Other Description CPX II|complexin II|complexin-2|synaphin 1|synaphin-1
Swissprots Q52M15 B2RAG2 Q6PUV4
Accessions EAW61366 EAW61367 Q6PUV4 AK055043 AK094266 AK124837 AK126590 AK293819 BAG57224 AK314177 BAG36859 AL512758 AL707430 AY576870 AAS93622 BC039560 BC052974 BC065485 BC093706 AAH93706 BC112287 AAI12288 BI197868 BN000499 CAG26663 BN000500 CAG26664 U35100 AAC50229 Y15167 XM_005265798 XP_005265855 XM_005265799 XP_005265856 XM_011534419 XP_011532721 NM_001008220 NP_001008221 NM_006650 NP_006641
Function Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.
Tissue Specificity Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia. {ECO:0000269|PubMed:11483314, ECO:0000269|PubMed:11576753, ECO:0000269|PubMed:15906159, ECO:0000269|PubMed:16162394, ECO:0000269|PubMed:9853440}.
Top Pathways Synaptic vesicle cycle

Complexin-1/2 (B-9) - sc-514321 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Complexin-1/2 (B-9): sc-514321. Western blot analysis of Complexin-1/2 expression in non-transfected 293T: sc-117752 (A) and human Complexin-1 transfected 293T: sc-110107 (B) whole cell lysates and human cerebral cortex tissue extract (C).

Complexin-1/2 (D-9) - sc-365152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Complexin-1/2 (D-9): sc-365152. Western blot analysis of Complexin-1 expression in non-transfected: sc-117752 (A) and human Complexin-1 transfected: sc-110107 (B) 293T whole cell lysates.

Complexin-1/2 (C-20) - sc-14529 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Complexin-1/2 (C-20): sc-14529. Western blot analysis of Complexin-1 expression in non-transfected: sc-117752 (A) and human Complexin-1 transfected: sc-110107 (B) 293T whole cell lysates.

Complexin-1/2 (FL-134) - sc-33603 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Complexin-1/2 (FL-134): sc-33603. Western blot analysis of Complexin-1 expression in non-transfected: sc-117752 (A) and humaan Complexin-1 transfected: sc-110107 (B) 293T whole cell lysates and mouse brain tissue extract (C).

Complexin-1/2 (N-14) - sc-14528 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Complexin-1/2 (N-14): sc-14528. Western blot analysis of Complexin-1 expression in non-transfected: sc-117752 (A) and human Complexin-1 transfected: sc-110107 (B) 293T whole cell lysates.

Anti-CPLX2 antibody - ab101857 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-CPLX2 / Complexin 2 Antibody (aa1-134) - LS-C125391 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal

Anti-CPLX2 / Complexin 2 Antibody (aa1-134, Biotin) - LS-C297268 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPLX2 / Complexin 2 Antibody (aa2-134, Biotin) - LS-C298047 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPLX2 / Complexin 2 Antibody (aa2-134, FITC) - LS-C301826 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPLX2 / Complexin 2 Antibody (aa1-134, FITC) - LS-C302989 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CPLX2 / Complexin 2 Antibody (N-Terminus) - LS-C116460 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CPLX2 antibody LS-C116460 Western blot of Fetal Liver lysate.

Anti-CPLX2 / Complexin 2 Antibody (aa1-134) - LS-C293502 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of recombinant CPLX2 / Complexin 2.

Anti-CPLX2 / Complexin 2 Antibody (aa2-134) - LS-C293501 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of recombinant CPLX2 / Complexin 2.

Anti-CPLX2 / Complexin 2 Antibody (aa51-83) - LS-C344349 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of lysate from mouse brain tissue with CPLX2 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35 ug.

Anti-CPLX2 / Complexin 2 Antibody (aa51-83) - LS-C344350 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of lysate from mouse brain tissue with CPLX2 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35 ug.

Complexin-2 Antibody - AF5085 from Novus Biologicals

Prices $99.00, $329.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of mouse, human, and rat brain tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat Complexin‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5085) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for Complexin‑2 at approximately 19 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2.

Complexin-2 Antibody - NBP1-57001 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

Complexin-2 Antibody - NBP1-46360 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-CPLX2 Polyclonal Antibody - bs-11342R from Bioss

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-CPLX2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11342R-A350 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-CPLX2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11342R-A488 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-CPLX2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11342R-A555 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-CPLX2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11342R-A647 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-CPLX2 Polyclonal Antibody, Cy3 Conjugated - bs-11342R-Cy3 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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