| Gene Symbol | PIK3C3 |
|---|---|
| Entrez Gene | 5289 |
| Alt Symbol | VPS34, Vps34 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatidylinositol 3-kinase, catalytic subunit type 3 |
| Other Description | PI3-kinase type 3|PI3K type 3|PtdIns-3-kinase type 3|phosphatidylinositol 3-kinase catalytic subunit type 3|phosphatidylinositol 3-kinase p100 subunit|phosphoinositide-3-kinase, class 3 |
| Swissprots | Q8NEB9 Q15134 |
| Accessions | EAX01426 Q8NEB9 AF131843 AK022653 AK090567 AK298517 BAG60721 AK308364 BC010388 BC033004 AAH33004 BC040982 BC053651 AAH53651 BI562123 CA945171 DB450556 DQ890552 ABM92169 DQ893712 ABM84638 Z46973 CAA87094 XM_011526030 XP_011524332 XM_011526031 XP_011524333 XR_935226 NM_001308020 NP_001294949 NM_002647 NP_002638 |
| Function | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. {ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:7628435}. |
| Subcellular Location | Midbody. Late endosome. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}. |
| Tissue Specificity | Ubiquitously expressed, with a highest expression in skeletal muscle. {ECO:0000269|PubMed:7628435}. |
| Top Pathways | Phagosome, Tuberculosis, Inositol phosphate metabolism, Regulation of autophagy, Phosphatidylinositol signaling system |