PIK3C3

Gene Symbol	PIK3C3
Entrez Gene	5289
Alt Symbol	VPS34, Vps34
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol 3-kinase, catalytic subunit type 3
Other Description	PI3-kinase type 3|PI3K type 3|PtdIns-3-kinase type 3|phosphatidylinositol 3-kinase catalytic subunit type 3|phosphatidylinositol 3-kinase p100 subunit|phosphoinositide-3-kinase, class 3
Swissprots	Q8NEB9 Q15134
Accessions	EAX01426 Q8NEB9 AF131843 AK022653 AK090567 AK298517 BAG60721 AK308364 BC010388 BC033004 AAH33004 BC040982 BC053651 AAH53651 BI562123 CA945171 DB450556 DQ890552 ABM92169 DQ893712 ABM84638 Z46973 CAA87094 XM_011526030 XP_011524332 XM_011526031 XP_011524333 XR_935226 NM_001308020 NP_001294949 NM_002647 NP_002638
Function	Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. {ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:7628435}.
Subcellular Location	Midbody. Late endosome. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed, with a highest expression in skeletal muscle. {ECO:0000269|PubMed:7628435}.
Top Pathways	Phagosome, Tuberculosis, Inositol phosphate metabolism, Regulation of autophagy, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PI 3 Kinase Class 3 full length protein - ab125629 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human PI 3 Kinase Class 3 full length protein - ab198071 from Abcam Category Protein Prices $359.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human PI 3 Kinase Class 3 full length protein - ab152608 from Abcam Category Protein Source Wheat germ Species Human

PIK3C3 / VPS34 Antibody Blocking Peptide - LS-E5955 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3C3 / VPS34 Antibody Blocking Peptide - LS-E5956 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3C3 / VPS34 Antibody Blocking Peptide - LS-E5957 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3C3 / VPS34 Antibody Blocking Peptide - LS-E5958 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3C3 / VPS34 Antibody Blocking Peptide - LS-E5959 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3C3 / VPS34 Antibody Blocking Peptide - LS-E7357 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3C3 / VPS34 Antibody Blocking Peptide - LS-E7356 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3C3 / VPS34 Antibody Blocking Peptide - LS-E7365 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3C3 / VPS34 Antibody Blocking Peptide - LS-E9427 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VPS34 Recombinant Protein - H00005289-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

VPS34 Peptide - P1534 from Novus Biologicals Category Peptide Species Human

VPS34 Peptide - P1507 from Novus Biologicals Category Peptide Species Human

VPS34 Peptide - P1506 from Novus Biologicals Category Peptide Species Human

PI3KC3-Antibody-S851-Blocking-Peptide - BP1851j from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI3KC3-Antibody-S425-Blocking-Peptide - BP1851h from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI3KC3-Antibody-S164-Blocking-Peptide - BP1851g from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI3KC3-Antibody-S34-Blocking-Peptide - BP1851e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI3KC3-Antibody-C-term-E785-Blocking-peptide - BP1851b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-PI3KC3S164-Antibody-Blocking-peptide - BP3399a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-PI3KC3S676-Antibody-Blocking-peptide - BP3369a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-PI3KC3S282-Antibody-Blocking-peptide - BP3368a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

PI3KC3-Antibody-N-term-Blocking-Peptide - BP8014a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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