PIK3C3

Gene Symbol PIK3C3
Entrez Gene 5289
Alt Symbol VPS34, Vps34
Species Human
Gene Type protein-coding
Description phosphatidylinositol 3-kinase, catalytic subunit type 3
Other Description PI3-kinase type 3|PI3K type 3|PtdIns-3-kinase type 3|phosphatidylinositol 3-kinase catalytic subunit type 3|phosphatidylinositol 3-kinase p100 subunit|phosphoinositide-3-kinase, class 3
Swissprots Q8NEB9 Q15134
Accessions EAX01426 Q8NEB9 AF131843 AK022653 AK090567 AK298517 BAG60721 AK308364 BC010388 BC033004 AAH33004 BC040982 BC053651 AAH53651 BI562123 CA945171 DB450556 DQ890552 ABM92169 DQ893712 ABM84638 Z46973 CAA87094 XM_011526030 XP_011524332 XM_011526031 XP_011524333 XR_935226 NM_001308020 NP_001294949 NM_002647 NP_002638
Function Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. {ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:7628435}.
Subcellular Location Midbody. Late endosome. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.
Tissue Specificity Ubiquitously expressed, with a highest expression in skeletal muscle. {ECO:0000269|PubMed:7628435}.
Top Pathways Phagosome, Tuberculosis, Inositol phosphate metabolism, Regulation of autophagy, Phosphatidylinositol signaling system

PIK3C3 cDNA (ANA11557) - ANA11557 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession NM_002647.2

Mouse PIK3C3 ORF clone (NM_002647.2) - CDCL149363 from Creative biogene

Species Human

Human PIK3C3 cDNA Clone(NM_002647.2) - CDFH014302 from Creative biogene

Species Human
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