KCNJ1

Gene Symbol KCNJ1
Entrez Gene 3758
Alt Symbol KIR1.1, ROMK, ROMK1
Species Human
Gene Type protein-coding
Description potassium channel, inwardly rectifying subfamily J, member 1
Other Description ATP-regulated potassium channel ROM-K|ATP-sensitive inward rectifier potassium channel 1|inward rectifier K(+) channel Kir1.1|inwardly rectifying K+ channel|potassium channel, inwardly rectifying subfamily J member 1|potassium inwardly-rectifying channel, subfamily J, member 1
Swissprots P48048 B2RMR4 Q6LD67
Accessions AAC51220 AAC51221 AAC51222 EAW67721 EAW67722 EAW67723 EAW67724 EAW67725 P48048 AI795925 AK290797 BAF83486 AK308032 AK308033 AK314267 AW611934 BC063109 BC074752 AAH74752 BC136360 AAI36361 BC136361 AAI36362 BE466312 DA622270 DA629130 DB199073 S78737 AAB35012 U03884 AAA20594 U12541 AAA61712 U12542 AAA61713 U12543 AAA61714 U12544 AAA61715 U12545 AAA61716 NM_000220 NP_000211 NM_153764 NP_722448 NM_153765 NP_722449 NM_153766 NP_722450 NM_153767 NP_722451
Function In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12684516}; Multi-pass membrane protein {ECO:0000269|PubMed:12684516}. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane.
Tissue Specificity In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. {ECO:0000269|PubMed:7635463}.
Top Pathways Aldosterone-regulated sodium reabsorption, Gastric acid secretion

ROM-K (D-3) - sc-393189 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ROM-K (D-3): sc-393189. Western blot analysis of ROM-K expression in non-transfected: sc-117752 (A) and mouse ROM-K transfected: sc-123254 (B) 293T whole cell lysates.

ROM-K (E-20) - sc-10694 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ROM-K (H-70) - sc-366595 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ROM-K (H-70): sc-366595. Western blot analysis of ROM-K expression in PANC-1 (A) and Caki-1 (B) whole cell lysates.

ROM-K (N-17) - sc-10692 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-KCNJ1 (phospho S44/25) antibody - ab111489 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111489, at 1/50 dilution, staining KCNJ1 in paraffin-embedded Human brain tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-KCNJ1 antibody - ab75906 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-KCNJ1 antibody (ab75906) at 1 µg/ml + HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-KCNJ1 antibody - ab85479 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-KCNJ1 antibody (ab85479) at 1 µg/ml (in 5% skim milk / PBS buffer) + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-KCNJ1 antibody - ab92285 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-KCNJ1 antibody (ab92285) at 1 µg/ml + Human Kidney lysate at 35 µgdeveloped using the ECL technique

Anti-KCNJ1 / ROMK Antibody (Cytoplasmic Domain) - LS-C94233 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNJ1 / ROMK Antibody (aa345-374, AP) - LS-C260911 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNJ1 / ROMK Antibody (aa345-374, APC) - LS-C260912 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNJ1 / ROMK Antibody (aa11-60) - LS-C117989 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of A549 cells, using ROMK/Kir1.1 (Ab-44/25) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-KCNJ1 / ROMK Antibody (aa345-374, Biotin) - LS-C260913 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNJ1 / ROMK Antibody (aa345-374, FITC) - LS-C260914 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNJ1 / ROMK Antibody (aa245-259) - LS-C112785 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
KCNJ1 antibody (1 ug/ml) staining of Human Kidney lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-KCNJ1 / ROMK Antibody (aa345-374, Azide-free, HRP) - LS-C260915 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNJ1 / ROMK Antibody (aa216-265) - LS-C101547 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KCNJ1 / Kir1.1 antibody LS-C101547 Western blot of HepG2 cell lysate.

Anti-KCNJ1 / ROMK Antibody (aa345-374, PE) - LS-C260916 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNJ1 / ROMK Antibody - LS-C285548 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNJ1 / ROMK Antibody (Biotin) - LS-C317367 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNJ1 / ROMK Antibody (HRP) - LS-C317369 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNJ1 / ROMK Antibody (FITC) - LS-C317368 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNJ1 / ROMK Antibody (aa326-355) - LS-C322388 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNJ1 / ROMK Antibody (phospho-Ser44/Ser25) - LS-C199545 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain, using ROMK/Kir1.1 (Phospho-Ser44/25) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-KCNJ1 / ROMK Antibody (aa345-374) - LS-C159974 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
KCNJ1 Antibody western blot of ZR-75-1 cell line lysates (35 ug/lane). The KCNJ1 antibody detected the KCNJ1 protein (arrow).
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