KCNJ1

Gene Symbol	KCNJ1
Entrez Gene	3758
Alt Symbol	KIR1.1, ROMK, ROMK1
Species	Human
Gene Type	protein-coding
Description	potassium channel, inwardly rectifying subfamily J, member 1
Other Description	ATP-regulated potassium channel ROM-K|ATP-sensitive inward rectifier potassium channel 1|inward rectifier K(+) channel Kir1.1|inwardly rectifying K+ channel|potassium channel, inwardly rectifying subfamily J member 1|potassium inwardly-rectifying channel, subfamily J, member 1
Swissprots	P48048 B2RMR4 Q6LD67
Accessions	AAC51220 AAC51221 AAC51222 EAW67721 EAW67722 EAW67723 EAW67724 EAW67725 P48048 AI795925 AK290797 BAF83486 AK308032 AK308033 AK314267 AW611934 BC063109 BC074752 AAH74752 BC136360 AAI36361 BC136361 AAI36362 BE466312 DA622270 DA629130 DB199073 S78737 AAB35012 U03884 AAA20594 U12541 AAA61712 U12542 AAA61713 U12543 AAA61714 U12544 AAA61715 U12545 AAA61716 NM_000220 NP_000211 NM_153764 NP_722448 NM_153765 NP_722449 NM_153766 NP_722450 NM_153767 NP_722451
Function	In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12684516}; Multi-pass membrane protein {ECO:0000269|PubMed:12684516}. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane.
Tissue Specificity	In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. {ECO:0000269|PubMed:7635463}.
Top Pathways	Aldosterone-regulated sodium reabsorption, Gastric acid secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KCNJ1 full length protein - ab132854 from Abcam Category Protein Source Wheat germ Species Human

Human KCNJ1 protein fragment - ab114590 from Abcam Category Protein Source Wheat germ Species Human

KCNJ1 peptide - ab86648 from Abcam Category Peptide

KCNJ1 / ROMK Antibody Blocking Peptide - LS-E6311 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNJ1 / ROMK Antibody Blocking Peptide - LS-E12597 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNJ1 / ROMK Antibody Blocking Peptide - LS-E26965 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human KCNJ1 Protein - H00003758-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human KCNJ1 Protein - H00003758-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

KCNJ1-Antibody-C-term-Blocking-Peptide - BP19000b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KCNJ1 / ROMK blocking peptide - GTX47558-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Recombinant human ATP-sensitive inward rectifier potassium channel 1 (OPCA00144) - OPCA00144 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Recombinant human ATP-sensitive inward rectifier potassium channel 1 (OPCA01264) - OPCA01264 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human KCNJ1 protein - orb244318 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human KCNJ1 protein - orb245895 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

KCNJ1 Blocking Peptide - 33R-5365 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KCNJ1 Peptide - AC21-1794-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

KCNJ1 - H00003758-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

KCNJ1 - H00003758-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

KCNJ1 - H00003758-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

KCNJ1 - H00003758-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KCNJ1 - H00003758-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

KCNJ1 Peptide - 42-072P from ProSci Category Peptide Species Human

KCNJ1 fusion protein - Ag15100 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human KCNJ1 - KCNJ1-28453TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant human ATP-sensitive inward rectifier potassium channel 1 - CSB-EP012047HU CSB-BP012047HU CSB-MP012047HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

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