| Gene Symbol | HDAC2 |
|---|---|
| Entrez Gene | 3066 |
| Alt Symbol | HD2, RPD3, YAF1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | histone deacetylase 2 |
| Other Description | YY1-associated factor 1|transcriptional regulator homolog RPD3 |
| Swissprots | Q92769 B4DL58 Q5SRI8 Q5SZ86 E1P561 B3KRS5 Q8NEH4 |
| Accessions | EAW48252 EAW48253 EAW48254 EAW48255 Q92769 AA704179 AB209190 BAD92427 AK092156 BAG52487 AK097376 BAG53457 AK296856 BAG59420 AV719958 BC013141 BC031055 AAH31055 BC146376 AAI46377 BC148797 AAI48798 BM550464 BP201509 CN304190 CN315003 U31814 AAC50814 XM_011535786 XP_011534088 XM_011535787 XP_011534089 XM_011535788 XP_011534090 NM_001527 NP_001518 NR_033441 NR_073443 |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-m |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:24970816}. Cytoplasm {ECO:0000269|PubMed:24970816}. |
| Tissue Specificity | Widely expressed; lower levels in brain and lung. |
| Top Pathways | Viral carcinogenesis, Alcoholism, Epstein-Barr virus infection, Cell cycle, Huntington's disease |