| Gene Symbol |
Map2k2
|
| Entrez Gene |
26396
|
| Alt Symbol |
AA589381, MEK2, MK2, Prkmk2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase 2
|
| Other Description |
ERK activator kinase 2|MAP kinase kinase 2|MAP kinase/Erk kinase|MAPK/ERK kinase 2|MAPKK 2|MEK 2|dual specificity mitogen-activated protein kinase kinase 2|mitogen activated protein kinase kinase 2|protein kinase, mitogen activated, kinase 2, p45
|
| Swissprots |
Q9D7B0 Q63932
|
| Accessions |
EDL31456 EDL31457 EDL31458 EDL31459 EDL31460 Q63932 AK009392 BAB26261 AK011247 AK036822 BAC29592 AK080574 BAC37945 AK138130 AK140101 BAE24237 AK143425 BAE25372 AK171584 BAE42542 AK172055 BAE42803 AK176974 AK181352 AK181608 AK186012 AK186466 AK188207 AK189608 AK192399 AK194767 AK196030 AK197970 AK198385 AK202988 AK203048 AK203356 AK208021 AK209603 AK210224 AK212183 AK212483 AK212487 AK214840 AK216389 AK217783 AK219722 AK220136 BC014830 AAH14830 BE955857 S68267 AAC60678 XM_006513682 XP_006513745 XM_006513683 XP_006513746 XM_006513684 XP_006513747 NM_023138 NP_075627
|
| Function |
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. {ECO:0000269|PubMed:19219045}.
|
| Tissue Specificity |
Expressed in adult intestine, kidney, liver, lung, pancreas, spleen, thymus, and at high levels in the neonatal brain. Lower expression is found in adult brain and heart.
|
| Top Pathways |
Gap junction, Bladder cancer, Chronic myeloid leukemia, Melanoma, Long-term depression
|