Runx2

Gene Symbol	Runx2
Entrez Gene	12393
Alt Symbol	AML3, Cbf, Cbfa-1, Cbfa1, LS3, Osf2, PEBP2aA, Pebp2a1, Pebpa2a
Species	Mouse
Gene Type	protein-coding
Description	runt related transcription factor 2
Other Description	AKV core binding factor|CBF-alpha-1|PEA2-alpha A|PEBP2 alpha A|SL3-3 enhancer factor 1 alpha A subunit|acute myeloid leukemia 3 protein|core binding factor alpha 1|osteoblast-specific transcription factor 2|polyomavirus enhancer-binding protein 2 alpha A subunit|runt domain, alpha subunit 1|runt-related transcription factor 2
Swissprots	Q08776 O35183 Q9R0U4 Q08775 Q9QY29 Q9Z2J7 Q9JLN0 Q9QUQ6
Accessions	AAC77440 AAF22568 AAF22569 BAA85345 BAA85346 EDL23422 Q08775 AF005936 AAB82419 AF010284 AAB65409 AF020681 AAD01649 AF053951 AAC78623 AF053954 AF053955 AF053956 AAC78626 AK089291 AK134925 AK137061 AK143355 AK158925 AK162373 AK164454 BC172607 AAI72607 BC172715 AAI72715 D14636 BAA03485 D14637 BAA03486 DQ458792 ABE68713 XM_006523540 XP_006523603 XM_006523541 XP_006523604 XM_006523542 XP_006523605 XM_006523543 XP_006523606 XM_006523544 XP_006523607 XM_006523545 XP_006523608 XM_006523546 XP_006523609 XM_006523547 XP_006523610 XM_006523548 XP_006523611 XR_385271 XR_385272 XR_385273 XR_385274 NM_001271633 NM_001145920 NP_001139392 NM_001146038 NP_001139510 NM_001271627 NP_001258556 NM_001271630 NP_001258559 NM_001271631 NP_001258560 NM_009820 NP_033950 NR_073392 NR_073425
Function	Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF- responsive element (OCFRE). {ECO:0000250, ECO:0000269|PubMed:20484411, ECO:0000269|PubMed:9182763}.
Subcellular Location	Nucleus.
Tissue Specificity	Found in thymus and testis, T-cell lines but not in B-cell lines. Isoform 2 is exclusively found in bone, particularly in osteoblasts; isoforms 3 and 4 are expressed in T- cell lines; isoforms 5, 6, 7, 8 and 9 can be found in osteoblasts and osteosarcoma cell lines.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Runt Related Transcription Factor 2 (RUNX2), Mouse, ELISA Kit - SEB011Mu from ARP American Research Products Category ELISA Kit Prices $704.00 Sizes 96 t Sensitivity 0.117ng/mL. Range 0.312-20ng/mL

Runt Related Transcription Factor 2, Mouse, ELISA Kit - E03R0098 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 1.0-25ng/mL,

Runt-related transcription factor 2 (RUNX2), Mouse, ELISA Kit - CSB-EL020594MO from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Runt-related transcription factor 2, Runx2, Mouse, ELISA Kit - E9029m from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t

Mouse RUNX2 ELISA Kit - MR0105 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse RUNX2(Runt Related Transcription Factor 2) ELISA Kit - E-EL-M1030 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Mouse RUNX2 (Runt Related Transcription Factor 2) CLIA Kit - E-CL-M0597 from Elabscience Category CLIA Kit Sensitivity 37.50 pg/mL Range Average Recovery (%)

Runt Related Transcription Factor 2, ELISA Kit - MBS726105 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Runt Related Transcription Factor 2, ELISA Kit - MBS037590 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

runt-related transcription factor 2, ELISA Kit - MBS934869 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of mouse RUNX2 is typically less than 0.78 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 3.12 ng/ml -200 ng/ml.

Mouse Runt-related transcription factor 2(RUNX2) ELISA kit - CSB-EL020594MO from Cusabio Category ELISA Kit Sensitivity 0.78ng/ml Range 3.12 ng/ml-200 ng/ml

Mouse Runt Related Transcription Factor 2 ELISA - E03R0098 from BlueGene Biotech Category ELISA Kit Sensitivity 0.1 ng/mL

ELISA Kit for Runt Related Transcription Factor 2 (RUNX2) - SEB011Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.116ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Mouse Runt Related Transcription Factor 2 (RUNX2) ELISA Kit - EKU07149 from Biomatik Category ELISA Kit Prices $718.00, $3,196.00, $5,817.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.116 ng/mL Range 0.312-20 ng/mL

Mouse POSTN/OSF-2(Periostin) ELISA Kit - E-EL-M0633 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mL Range 0.16~10 ng/mL

Mouse RUNX2(Runt Related Transcription Factor 2) ELISA Kit - E-EL-M1030 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.19 ng/mL Range 0.31~20 ng/mL

Mouse IL-9 (Interleukin 9) CLIA Kit - E-CL-M0457 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 9.375pg/mL Range 15.625-1000pg/mL

Mouse Runt Related Transcription Factor 2 ELISA Kit - abx254390 from Abbexa Category ELISA Kit Sensitivity 0.188 ng/ml Range 0.313 ng/ml - 20 ng/ml

Mouse RUNX2 ELISA Kit - abx154623 from Abbexa Category ELISA Kit Sensitivity 0.117 ng/ml. Range 0.313 ng/ml - 20 ng/ml

Runt Related Transcription Factor 2 (RUNX2), Mouse, ELISA Kit - DL-RUNX2-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.312-20 ng/mL

Mouse RUNX2 ELISA Kit - abx572609 from Abbexa Category ELISA Kit Sensitivity 0.117 ng/ml Range 0.313 ng/ml - 20 ng/ml

Mouse Runt-related transcription factor 2 (RUNX2) ELISA Kit - EKC37758 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.78 ng/ml Range 3.12 ng/ml-200 ng/ml

RUNX2 - EKM2668 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.313--20ng/ml

Mouse Runx2 ELISA Kit - E066828 from Biobool Category ELISA Kit

Mouse RUNX2 ELISA Kit - EMR0105 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

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