| Gene Symbol |
Runx2
|
| Entrez Gene |
12393
|
| Alt Symbol |
AML3, Cbf, Cbfa-1, Cbfa1, LS3, Osf2, PEBP2aA, Pebp2a1, Pebpa2a
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
runt related transcription factor 2
|
| Other Description |
AKV core binding factor|CBF-alpha-1|PEA2-alpha A|PEBP2 alpha A|SL3-3 enhancer factor 1 alpha A subunit|acute myeloid leukemia 3 protein|core binding factor alpha 1|osteoblast-specific transcription factor 2|polyomavirus enhancer-binding protein 2 alpha A subunit|runt domain, alpha subunit 1|runt-related transcription factor 2
|
| Swissprots |
Q08776 O35183 Q9R0U4 Q08775 Q9QY29 Q9Z2J7 Q9JLN0 Q9QUQ6
|
| Accessions |
AAC77440 AAF22568 AAF22569 BAA85345 BAA85346 EDL23422 Q08775 AF005936 AAB82419 AF010284 AAB65409 AF020681 AAD01649 AF053951 AAC78623 AF053954 AF053955 AF053956 AAC78626 AK089291 AK134925 AK137061 AK143355 AK158925 AK162373 AK164454 BC172607 AAI72607 BC172715 AAI72715 D14636 BAA03485 D14637 BAA03486 DQ458792 ABE68713 XM_006523540 XP_006523603 XM_006523541 XP_006523604 XM_006523542 XP_006523605 XM_006523543 XP_006523606 XM_006523544 XP_006523607 XM_006523545 XP_006523608 XM_006523546 XP_006523609 XM_006523547 XP_006523610 XM_006523548 XP_006523611 XR_385271 XR_385272 XR_385273 XR_385274 NM_001271633 NM_001145920 NP_001139392 NM_001146038 NP_001139510 NM_001271627 NP_001258556 NM_001271630 NP_001258559 NM_001271631 NP_001258560 NM_009820 NP_033950 NR_073392 NR_073425
|
| Function |
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF- responsive element (OCFRE). {ECO:0000250, ECO:0000269|PubMed:20484411, ECO:0000269|PubMed:9182763}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Found in thymus and testis, T-cell lines but not in B-cell lines. Isoform 2 is exclusively found in bone, particularly in osteoblasts; isoforms 3 and 4 are expressed in T- cell lines; isoforms 5, 6, 7, 8 and 9 can be found in osteoblasts and osteosarcoma cell lines.
|
| Top Pathways |
Transcriptional misregulation in cancer
|