CACNA2D1

Gene Symbol CACNA2D1
Entrez Gene 781
Alt Symbol CACNA2, CACNL2A, CCHL2A, LINC01112, lncRNA-N3
Species Human
Gene Type protein-coding
Description calcium channel, voltage-dependent, alpha 2/delta subunit 1
Other Description calcium channel, L type, alpha 2 polypeptide|dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit|voltage-dependent calcium channel subunit alpha-2/delta-1|voltage-gated calcium channel subunit alpha-2/delta-1
Swissprots Q9UD82 Q17R45 Q9UD80 Q9UD81 P54289
Accessions AAC78619 AAD20938 AAD51454 AAF03259 AAF19234 EAW76990 P54289 AI924415 AK055040 AK092048 AK299838 BAH13144 AL707206 AL833141 BC051339 BC117468 AAI17469 BC117470 AAI17471 BG055272 BI545104 BP258070 BU501177 M76559 AAA51903 XM_005250570 XP_005250627 XM_005250572 XP_005250629 XM_005250573 XP_005250630 XM_005250574 XP_005250631 XM_006716118 XP_006716181 XM_006716119 XP_006716182 XM_006716120 XP_006716183 XM_006716121 XP_006716184 XM_011516570 XP_011514872 XM_011516571 XP_011514873 XM_011516572 XP_011514874 XM_011516573 XP_011514875 XM_011516574 XP_011514876 NM_000722 NP_000713 NM_001302890 NP_001289819
Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity). {ECO:0000250}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta. {ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:8107964}.
Top Pathways MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy

Cacna2d1 (E-10) - sc-271697 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cacna2d1 (E-10): sc-271697. Western blot analysis of Cacna2d1 expression in HeLa whole cell lysate.

Cacna2d1 (H-147) - sc-98693 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Cacna2d1 (K-14) - sc-104118 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Cacna2d1 (N-17) - sc-104119 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Cacna2d1 (V-21) - sc-133436 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
Cacna2d1 (V-21): sc-133436. Western blot analysis of Cacna2d1 expression in human fetal muscle tissue extract.

Anti-Calcium channel L type DHPR alpha 2 subunit antibody - ab80990 from Abcam

Prices $378.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of mouse superior cervical ganglion cells, staining Calcium channel L type DHPR alpha 2 subunit with ab80990. Cells were fixed with paraformaldehye, permeablized 0.5% Triton X-100 and blocked with normal chicken serum for 30 min at room temperature. Samples were incubated overnight with primary antibody (1/100 followed by incubation for 1 hour with an AlexaFluor®-conjugated anti-rabbit secondary antibody (1/500).

Anti-Calcium channel L type DHPR alpha 2 subunit antibody - ab133381 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin embedded Human nerve tissue labelling Calcium channel L type DHPR alpha 2 subunit with ab133381 at 10µg/ml. Followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Calcium channel L type DHPR alpha 2 subunit antibody - ab65266 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D1 Antibody (N-Terminus) - LS-C94043 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D1 Antibody (N-Terminus) - LS-C26751 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of 2/ antibody on rat brain lysate at 5 ug/ml.

Anti-CACNA2D1 Antibody - LS-C153508 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D1 Antibody (N-Terminus, AP) - LS-C224936 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D1 Antibody (N-Terminus, Biotin) - LS-C224937 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D1 Antibody (clone 20A) IHC-plus™ - LS-B6795 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 20A
Anti-CACNA2D1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6795 dilution 1:50.

Anti-CACNA2D1 Antibody (aa370-383) - LS-C54598 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.03 ug/ml) staining of Human Brain (Cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CACNA2D1 Antibody (N-Terminus, FITC) - LS-C224938 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D1 Antibody (Glu139) - LS-C177234 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Cacna2d1 (E139) pAb in extracts from 3T3 cells.

Anti-CACNA2D1 Antibody (N-Terminus, APC) - LS-C224939 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D1 Antibody (N-Terminus, PE) - LS-C224941 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D1 Antibody (N-Terminus) - LS-C326981 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D1 Antibody (aa90-139) - LS-C199780 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Cacna2d1 antibody in extracts from 3T3 cells.

Anti-CACNA2D1 Antibody (N-Terminus, Azide-free, HRP) - LS-C224940 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D1 Antibody (aa47-76) - LS-C168257 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of CACNA2D1 Antibody in mouse brain tissue lysates (35 ug/lane). CACNA2D1 (arrow) was detected using the purified antibody.

Anti-CACNA2D1 Antibody IHC-plus™ - LS-B6739 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CACNA2D1 antibody IHC of human nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6739 concentration 10 ug/ml.

Anti-CACNA2D1 Antibody (aa532-581) IHC-plus™ - LS-B162 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CACNA2D1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B162 concentration 2.5 ug/ml.
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