| Gene Symbol |
SLIT1
|
| Entrez Gene |
6585
|
| Alt Symbol |
MEGF4, SLIL1, SLIT-1, SLIT3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
slit homolog 1 (Drosophila)
|
| Other Description |
multiple EGF-like domains protein 4|multiple epidermal growth factor-like domains protein 4|slit homolog 1 protein
|
| Swissprots |
Q9UIL7 Q8WWZ2 Q5T0V1 O75093
|
| Accessions |
EAW49956 EAW49957 EAW49958 EAW49959 O75093 AB011537 BAA32465 AB017167 BAA35184 AY029183 AAK31796 BC028105 BC139909 BC146761 AAI46762 BC146851 AAI46852 CD671648 NM_003061 NP_003052
|
| Function |
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney. {ECO:0000269|PubMed:9813312}.
|
| Top Pathways |
Axon guidance
|