ITGA2B

Gene Symbol ITGA2B
Entrez Gene 3674
Alt Symbol BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93
Species Human
Gene Type protein-coding
Description integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Other Description GPalpha IIb|integrin alpha-IIb|platelet fibrinogen receptor, alpha subunit|platelet membrane glycoprotein IIb|platelet-specific antigen BAK|protein phosphatase 1, regulatory subunit 93
Swissprots Q14443 P08514 B2RCY8 Q17R67 O95366
Accessions AAA52587 AAA52588 AAA52598 AAA52599 AAA53150 ADZ28529 ADZ28530 ADZ55421 AFN53559 EAW51594 EAW51595 EAW51596 EAW51597 P08514 AB209552 BAD92789 AF098114 AAC98507 AK297155 BAG59654 AK303081 BAH13896 AK315335 BAG37735 BC117443 AAI17444 BC126442 AAI26443 BE409167 BM148153 DQ841705 ABI15196 J02764 AAA60114 M18085 AAA52597 M34480 AAA35926 X06831 CAA29987 XM_011524749 XP_011523051 XM_011524750 XP_011523052 NM_000419 NP_000410
Function Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
Top Pathways Hypertrophic cardiomyopathy (HCM), Rap1 signaling pathway, PI3K-Akt signaling pathway, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Integrin α2b (D8V7H) Rabbit mAb - 13807 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8V7H
Western blot analysis of extracts from various cell lines using Integrin α2b (D8V7H) Rabbit mAb (upper) and GAPDH (D16H11) XP ® Rabbit mAb #5174 (lower). As expected, K-562 and HL-60 are negative for integrin α2b.

Integrin α2b Antibody - 9028 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Integrin αIIb (B-10) - sc-166599 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin αIIb (B-10): sc-166599. Western blot analysis of Integrin αIIb expression in HEL 92.1.7 whole cell lysate.

Integrin αIIb (B-9) - sc-365938 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin αIIb (B-9): sc-365938. Western blot analysis of Integrin αIIb expression in HEL 92.1.7 whole cell lysate.

Integrin αIIb (H-160) - sc-15328 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Integrin αIIb (H-160): sc-15328. Western blot analysis of Integrin αIIb expression in human platelet extract (A), MEG-01 (B) and HEL 92.1.7 (C) whole cell lysates.

Integrin αIIb (C-20) - sc-6602 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin αIIb (C-20): sc-6602. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse testis showing membrane localization.

Integrin αIIb (A-7) - sc-373992 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin αIIb (A-7): sc-373992. Western blot analysis of Integrin αIIb expression in HEL 92.1.7 whole cell lysate.

Integrin αIIb (K-18) - sc-6604 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin αIIb (K-18): sc-6604. Western blot analysis of Integrin αIIb expression in HEL 92.1.7 whole cell lysate.

Integrin αIIb (96-2C1) - sc-21773 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin αIIb (96-2C1): sc-21773. Western blot analysis of Integrin αIIb expression in human platelet extract (A) and human PBL (B) whole cell lysates under non-reducing conditions.

Integrin αIIb (SZ.22) - sc-59923 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Integrin αIIb (M-148) - sc-7310 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin αIIb (M-148) PE: sc-7310 PE. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>.

Integrin α2/β1 (16B4) - sc-59955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Integrin α2/β1 (2B2.29) - sc-71429 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Integrin α2/β1 (3H1472) - sc-71430 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Integrin αIIb/β3 (A2A9/6) - sc-21783 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin αIIb/β3 (A2A9/6): sc-21783. Western blot analysis of Integrin αIIb and β3 expression in human platelet extract under non-reducing conditions.

Integrin αIIb/β3 (P256) - sc-53358 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin αIIb/β3 (P256): sc-53358. Western blot analysis of Integrin αIIb and β3 expression in human platelet extract under non-reducing conditions.

Integrin αIIb/β3 (474) - sc-52816 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Integrin αIIb/β3 (474): sc-52816. Western blot analysis of Integrin αIIb/β3 expression in human PBL whole cell lysate.

Anti-CD41 antibody - ab63983 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD41 antibody (ab63983) at 1/10000 dilutionLane 1 : HeLa whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 25 µg per lane.SecondaryHRP-conjugated goat anti-rabbit IgG polyclonal at 1/20000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CD41 antibody [EPR4330] - ab134131 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4330
All lanes : Anti-CD41 antibody [EPR4330] (ab134131) at 1/1000 dilutionLane 1 : Human platelet lysateLane 2 : Human fetal liver lysateLane 3 : Human placenta lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti rabbit at 1/2000 dilution

Anti-CD41 antibody [EPR4330] (HRP) - ab194981 from Abcam

Prices $431.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4330
Anti-CD41 antibody [EPR4330] (HRP) (ab194981) at 1/5000 dilution + Platelet (Human) Whole Cell Lysate at 10 µgdeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CD41 antibody [HIP2] - ab15026 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone HIP2

Anti-CD41 antibody [HIP8] - ab15021 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone HIP8

Anti-CD41 antibody [HIP8] (CF405M) - ab119497 from Abcam

Prices $376.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone HIP8
ab119497, at 5 µl/106 cells, staining CD41/Integrin alpha 2b in Human platelets in normal peripheral blood cells by Flow Cytometry. Total events were used for the analysis.

Anti-CD41 antibody [M148] - ab11024 from Abcam

Prices $400.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone M148
IHC-Fr image of C41 staining on human blood film using ab11024 (1:1000). The sample was fixed using paraformaldehyde and permeabilized using 0.1% TritonX in 0.1% PBS. The slides were then blocked with 10% Donkey Serum for 1 hr at 24°C. ab11024 was diluted 1:100 using 0.1% TritonX with 0.1x PBS- 10% Donkeys and slides were incubated with the primary antibody for 4 hours at 24°C. The secondary antibody used was Donkey Polyclonal to rabbit IgG conjugated to Alexa Fuor 568 (1:1000)See Abreview

Anti-CD41 antibody [M148] (Biotin) - ab19699 from Abcam

Prices $185.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone M148
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