ITGA2B

Gene Symbol	ITGA2B
Entrez Gene	3674
Alt Symbol	BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93
Species	Human
Gene Type	protein-coding
Description	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Other Description	GPalpha IIb|integrin alpha-IIb|platelet fibrinogen receptor, alpha subunit|platelet membrane glycoprotein IIb|platelet-specific antigen BAK|protein phosphatase 1, regulatory subunit 93
Swissprots	Q14443 P08514 B2RCY8 Q17R67 O95366
Accessions	AAA52587 AAA52588 AAA52598 AAA52599 AAA53150 ADZ28529 ADZ28530 ADZ55421 AFN53559 EAW51594 EAW51595 EAW51596 EAW51597 P08514 AB209552 BAD92789 AF098114 AAC98507 AK297155 BAG59654 AK303081 BAH13896 AK315335 BAG37735 BC117443 AAI17444 BC126442 AAI26443 BE409167 BM148153 DQ841705 ABI15196 J02764 AAA60114 M18085 AAA52597 M34480 AAA35926 X06831 CAA29987 XM_011524749 XP_011523051 XM_011524750 XP_011523052 NM_000419 NP_000410
Function	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
Top Pathways	Hypertrophic cardiomyopathy (HCM), Rap1 signaling pathway, PI3K-Akt signaling pathway, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ITGA2B / CD41 ELISA Kit (Sandwich ELISA) - LS-F9332 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 0.156-10 ng/ml

Mouse ITGA2B / CD41 ELISA Kit (Sandwich ELISA) - LS-F11843 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Human ITGA2B / CD41 ELISA Kit (Sandwich ELISA) - LS-F11844 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Platelet Membrane Glycoprotein IIb/IIIa complex, GPIIb/IIIa, Human, ELISA Kit - E-EL-H2202 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Integrin Alpha 2B (ITGa2B), Human, ELISA Kit - SEB029Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.052ng/mL Range 0.156-10ng/mL

Integrin alpha-IIb (ITGA2B), Human, ELISA Kit - CSB-EL011865HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Integrin alpha-IIb, ITGA2B, Human, ELISA Kit - E0614h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Platelet Membrane Glycoprotein IIb/IIIa, GPIIb/IIIa, Rabbit, ELISA Kit - E-EL-RB0740 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Platelet Membrane Glycoprotein IIb/IIIa, GPIIb/IIIa, Chicken, ELISA Kit - E-EL-Ch1792 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Platelet Membrane Glycoprotein IIb/IIIa, GPIIb/IIIa, Porcine, ELISA Kit - E-EL-P0931 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.375 Range 0.625-40ng/mL

Platelet Membrane Glycoprotein IIb/IIIa, GPIIb/IIIa, Sheep, ELISA Kit - E-EL-S0929 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t Sensitivity 46.875 Range 78.125-5000pg/mL

Platelet Membrane Glycoprotein IIb/IIIa, GPIIb/IIIa, Guinea Pig, ELISA Kit - E-EL-GP0788 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Platelet Membrane Glycoprotein IIb/IIIa, GPIIb/IIIa, Monkey, ELISA Kit - E-EL-MK0801 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

ITGA2B/ITGB3 (Human) ELISA kit - KA0477 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

GPIIb/IIIa, ELISA Kit - MBS2510923 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

Platelet membrane glycoprotein IIb (GPIIb) , ELISA Kit - MBS706073 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.039ng/ml Range 0.156-10 ng/ml

ITGA2B/ITGB3 (Human) ELISA Kit - DEIA3823 from Creative Diagnostics Category ELISA Kit Sensitivity The minimum detectable dose of GPIIb/IIIa is typically

Human GPIIb/IIIa (Platelet Membrane Glycoprotein IIb/IIIa) CLIA Kit - E-CL-H1305 from Elabscience Category CLIA Kit Sensitivity 0.094ng/mL Range 0.156~10ng/mL

Integrin Alpha 2B (ITGa2B), ELISA Kit - MBS2019592 from MyBioSource Category ELISA Kit Prices $355.00, $540.00, $730.00, $2,985.00, $5,410.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.055ng/mL. Range 0.156-10ng/mL

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) , ELISA Kit - MBS923777 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human ITGA2B is typically less than 0.039 ng/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0. 156 ng/ml -10 ng/ml.

ELISA Kit for Integrin Alpha 2B (ITGa2B) - SEB029Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Integrin alpha-IIb(ITGA2B) ELISA kit - CSB-EL011865HU from Cusabio Category ELISA Kit Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Human GPIIbIIIa ELISA Kit - EG1060-1 from AssayPro Category ELISA Kit Range 1.25-40 ng/ml

ELISA Kit for Integrin Alpha 2B (ITGa2B) - SEB029Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

GPIIb/IIIa - KSP-448 from Nordic BioSite Range 1.25-40 ng/ml

Search more