| Gene Symbol | E2F4 |
|---|---|
| Entrez Gene | 1874 |
| Alt Symbol | E2F-4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | E2F transcription factor 4, p107/p130-binding |
| Other Description | p107/p130-binding protein|transcription factor E2F4 |
| Swissprots | Q15328 Q16254 Q12991 A6NGR8 B5BU56 |
| Accessions | AAF65226 AAM77918 CBX53825 EAW83094 EAW83095 EAW83096 Q16254 AB451292 BAG70106 AB451425 BAG70239 BC021050 BC031071 BC033180 AAH33180 BU857680 DQ892803 ABM83729 S75174 AAB32597 U15641 AAC50119 X86096 CAA60050 NM_001950 NP_001941 |
| Function | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Top Pathways | Cell cycle, TGF-beta signaling pathway |