E2F4

Gene Symbol E2F4
Entrez Gene 1874
Alt Symbol E2F-4
Species Human
Gene Type protein-coding
Description E2F transcription factor 4, p107/p130-binding
Other Description p107/p130-binding protein|transcription factor E2F4
Swissprots Q15328 Q16254 Q12991 A6NGR8 B5BU56
Accessions AAF65226 AAM77918 CBX53825 EAW83094 EAW83095 EAW83096 Q16254 AB451292 BAG70106 AB451425 BAG70239 BC021050 BC031071 BC033180 AAH33180 BU857680 DQ892803 ABM83729 S75174 AAB32597 U15641 AAC50119 X86096 CAA60050 NM_001950 NP_001941
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}.
Subcellular Location Nucleus.
Tissue Specificity Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Top Pathways Cell cycle, TGF-beta signaling pathway

E2F-4 CRISPR/Cas9 KO Plasmid (h) - sc-400851 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

E2F-4 HDR Plasmid (h) - sc-400851-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

E2F-4 Double Nickase Plasmid (h) - sc-400851-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

E2F-4 Double Nickase Plasmid (h2) - sc-400851-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

E2F-4 CRISPR Activation Plasmid (h) - sc-400851-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

E2F-4 CRISPR Activation Plasmid (h2) - sc-400851-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

E2F-4 Lentiviral Activation Particles (h) - sc-400851-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

E2F-4 Lentiviral Activation Particles (h2) - sc-400851-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

E2F-4 siRNA (h) - sc-29300 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

E2F-4 shRNA Plasmid (h) - sc-29300-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

E2F-4 shRNA (h) Lentiviral Particles - sc-29300-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

E2F-4 RNAi - H00001874-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU102701 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2036 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2036 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

E2F4 siRNA (Human) - CRH1309 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

E2F4 - MBS8221261 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human E2F4(NM_001950.3) - SHH021863 from Creative biogene

Category siRNA
Species Reactivities Human

E2F4 shRNA Plasmid (Human) - CHH1309 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

E2F4 miRNA 3'UTR clone - MiUTR1H-03074 from Creative biogene

Species Reactivities Human
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