| Gene Symbol |
E2F4
|
| Entrez Gene |
1874
|
| Alt Symbol |
E2F-4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
E2F transcription factor 4, p107/p130-binding
|
| Other Description |
p107/p130-binding protein|transcription factor E2F4
|
| Swissprots |
Q15328 Q16254 Q12991 A6NGR8 B5BU56
|
| Accessions |
AAF65226 AAM77918 CBX53825 EAW83094 EAW83095 EAW83096 Q16254 AB451292 BAG70106 AB451425 BAG70239 BC021050 BC031071 BC033180 AAH33180 BU857680 DQ892803 ABM83729 S75174 AAB32597 U15641 AAC50119 X86096 CAA60050 NM_001950 NP_001941
|
| Function |
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
|
| Top Pathways |
Cell cycle, TGF-beta signaling pathway
|
![Western Blot: E2F4 Overexpression Lysate (Adult Normal) [NBL1-10085] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for E2F4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1036_E2F4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10085-img0002.jpg)