| Gene Symbol | OXCT1 |
|---|---|
| Entrez Gene | 5019 |
| Alt Symbol | OXCT, SCOT |
| Species | Human |
| Gene Type | protein-coding |
| Description | 3-oxoacid CoA transferase 1 |
| Other Description | 3-oxoacid CoA-transferase 1|3-oxoacid-CoA transferase 1|SCOT-s|somatic-type succinyl CoA:3-oxoacid CoA-transferase|somatic-type succinyl-CoA:3-oxoacid CoA-transferase|somatic-type succinyl-CoA:3-oxoacid-CoA-transferase|succinyl CoA:3-oxoacid CoA transferase|succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial|succinyl-CoA:3-ketoacid-CoA transferase|succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial |
| Swissprots | P55809 B7Z528 B2R5V2 |
| Accessions | BAB13733 BAC19838 CBX51364 EAW56014 EAW56015 P55809 AK125115 AK298352 BAH12764 AK299668 BAH13095 AK312327 BAG35249 AK315902 BAH14273 BC009001 AAH09001 BE244429 CR457049 CAG33330 DQ891805 ABM82731 DQ894989 ABM85915 EF095213 ABL01517 U62961 AAB07366 XR_427658 NM_000436 NP_000427 |
| Function | Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. |
| Subcellular Location | Mitochondrion matrix. |
| Tissue Specificity | Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts. |
| Top Pathways | Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism |