ATP2A1

Gene Symbol ATP2A1
Entrez Gene 487
Alt Symbol ATP2A, SERCA1
Species Human
Gene Type protein-coding
Description ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Other Description SR Ca(2+)-ATPase 1|calcium pump 1|calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform|endoplasmic reticulum class 1/2 Ca(2+) ATPase|sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Swissprots O14983 A8K5J9 B3KY17 O14984
Accessions AAB53112 AAB53113 CBG22289 CBV35450 EAW52006 O14983 AK092691 BAG52597 AK128456 BAG54679 AK291314 BAF84003 AL706356 BC037354 AAH37354 BC104452 BC104453 BC148653 AAI48654 BU737186 BX537389 CAD97631 BX537784 CAD97841 BX647365 BX647366 BX647367 BX647368 BX648544 BX649072 EF139859 EF139860 NM_001286075 NP_001273004 NM_004320 NP_004311 NM_173201 NP_775293
Function Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity Skeletal muscle, fast twitch muscle (type II) fibers.
Top Pathways Alzheimer's disease, Calcium signaling pathway, Pancreatic secretion, cGMP-PKG signaling pathway

ATP2A1/SERCA1 (L24) Antibody - 4219 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from human skeletal muscle using ATP2A1/SERCA1 (L24) Antibody.

ATP2A1/SERCA1 (A988) Antibody - 4274 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of mouse skeletal muscle extracts using ATP2A1/SERCA1 (A988) Antibody.

ATP2A1/SERCA1 (D54G12) Rabbit mAb - 12293 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D54G12
Western blot analysis of extracts from human skeletal muscle and mouse skeletal muscle using ATP2A1/SERCA1 (D54G12) Rabbit mAb.

SERCA1 (G-8) - sc-365098 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SERCA1 (G-8): sc-365098. Western blot analysis of SERCA1 expression in rat skeletal muscle tissue extract.

SERCA1 (N-19) - sc-8093 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SERCA1 (N-19): sc-8093. Western blot analysis of SERCA1 expression in rat skeletal muscle tissue extract.

SERCA1 (VE121G9) - sc-58287 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SERCA1 (VE121G9): sc-58287. Western blot analysis of SERCA1 expression in rabbit muscle tissue extract.

SERCA1 (F-18) - sc-12493 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SERCA1 (F-18): sc-12493. Western blot analysis of SERCA1 expression in A-10 whole cell lysate.

SERCA1 (4i390) - sc-73020 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

SERCA1 (6D138) - sc-73019 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

SERCA1/2/3 (B-7) - sc-271669 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SERCA1/2/3 (B-7): sc-271669. Western blot analysis of SERCA3 expression in non-transfected: sc-117752 (A) and mouse SERCA3 transfected: sc-125983 (B) 293T whole cell lysates.

SERCA1/2/3 (H-300) - sc-30110 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SERCA1/2/3 (H-300): sc-30110. Western blot analysis of SERCA1, 2 and 3 expression in T98G whole cell lysate.

Anti-SERCA1 ATPase antibody - ab92666 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab92666 stained HeLa cells. The cells were 100% Methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab92666, 1µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-SERCA1 ATPase antibody - ab105172 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SERCA1 ATPase antibody (ab105172) at 1 µg/mlLane 1 : Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330)Lane 2 : Skeletal Muscle (Mouse) Tissue LysateLane 3 : Skeletal Muscle (Rat) Tissue LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SERCA1 ATPase antibody - ab104761 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-SERCA1 ATPase antibody [EPR7321] - ab133275 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7321
Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue labelling SERCA1 ATPase using ab133275, at 1/100 dilution.

Anti-SERCA1 ATPase antibody [EPR7322] - ab129104 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7322
All lanes : Anti-SERCA1 ATPase antibody [EPR7322] (ab129104) at 1/1000 dilutionLane 1 : Human fetal muscle lysateLane 2 : Rat muscle lysateLane 3 : Mouse muscle lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-SERCA1 ATPase antibody [VE121G9] - ab2819 from Abcam

Prices $401.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone VE121G9
Immunocytochemistry/Immunofluorescence analysis of SERCA1 ATPase shows staining in A2058 cells. SERCA1 ATPase staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were incubated without (control) or with or ab2819 (1:20) overnight at 4°C, washed with PBS and incubated with a DyLight-488 conjugated goat anti-mouse IgG secondary antibody. Images were taken at 60X magnification.

Anti-ATP2A1 / SERCA1 Antibody (aa665-680) - LS-C312871 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ATP2A1 / SERCA1 antibody. IHC(P): Rat Skeletal Muscle Tissue.

Anti-ATP2A1 / SERCA1 Antibody (clone 1B11) IHC-plus™ - LS-B4285 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1B11
Anti-SERCA1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4285 concentration 5 ug/ml.

Anti-ATP2A1 / SERCA1 Antibody (aa199-505) - LS-C12014 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-ATP2A1 / SERCA1 Antibody (C-Terminus) - LS-C12015 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-ATP2A1 / SERCA1 Antibody - LS-C12017 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-ATP2A1 / SERCA1 Antibody - LS-C12018 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-ATP2A1 / SERCA1 Antibody - LS-C132042 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP2A1 / SERCA1 Antibody - LS-C132043 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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