| Gene Symbol | ATP2A1 |
|---|---|
| Entrez Gene | 487 |
| Alt Symbol | ATP2A, SERCA1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 |
| Other Description | SR Ca(2+)-ATPase 1|calcium pump 1|calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform|endoplasmic reticulum class 1/2 Ca(2+) ATPase|sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
| Swissprots | O14983 A8K5J9 B3KY17 O14984 |
| Accessions | AAB53112 AAB53113 CBG22289 CBV35450 EAW52006 O14983 AK092691 BAG52597 AK128456 BAG54679 AK291314 BAF84003 AL706356 BC037354 AAH37354 BC104452 BC104453 BC148653 AAI48654 BU737186 BX537389 CAD97631 BX537784 CAD97841 BX647365 BX647366 BX647367 BX647368 BX648544 BX649072 EF139859 EF139860 NM_001286075 NP_001273004 NM_004320 NP_004311 NM_173201 NP_775293 |
| Function | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein. |
| Tissue Specificity | Skeletal muscle, fast twitch muscle (type II) fibers. |
| Top Pathways | Alzheimer's disease, Calcium signaling pathway, Pancreatic secretion, cGMP-PKG signaling pathway |