CHST4

Gene Symbol CHST4
Entrez Gene 10164
Alt Symbol GST3, GlcNAc6ST2, HECGLCNAC6ST, LSST
Species Human
Gene Type protein-coding
Description carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
Other Description GST-3|HEC-GlcNAc6ST|L-selectin ligand sulfotransferase|N-acetylglucosamine 6-O-sulfotransferase 2|carbohydrate sulfotransferase 4|galactose/N-acetylglucosamine/N-acetylgalactosamine 6-O-sulfotransferase 3|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3|glcNAc6ST-2|gn6st-2|high endothelial cells N-acetylglucosamine 6-O-sulfotransferase
Swissprots Q9Y5R3 Q8NCG5 Q8IV46
Accessions EAW59235 Q8NCG5 AF131235 AAD33015 AF149783 AAK48417 AF280088 AAG48246 AK026635 AK074746 BAC11177 AL709927 BC035282 AAH35282 DA045171 DA496702 DQ892110 ABM83036 DQ895304 ABM86230 NM_001166395 NP_001159867 NM_005769 NP_005760
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2- branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1- 3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location.
Subcellular Location Golgi apparatus membrane {ECO:0000269|PubMed:12855678}; Single-pass type II membrane protein {ECO:0000269|PubMed:12855678}.
Tissue Specificity Specifically expressed in HEV. Weakly expressed in spleen. Not expressed in other tissues. Expressed in colonic mucinous adenocarcinoma. {ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:11310842, ECO:0000269|PubMed:12107080}.
Top Pathways Glycosaminoglycan biosynthesis - keratan sulfate

Carbohyde sulfotransferase 4 (CHST4), Human, ELISA Kit - E01C1711 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Carbohyde sulfotransferase 4 (CHST4), ELISA Kit - MBS7238932 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Carbohyde sulfotransferase 4 (CHST4), ELISA Kit - MBS7243288 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Carbohyde sulfotransferase 4 (CHST4), ELISA Kit - MBS7245933 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Carbohyde sulfotransferase 4 (CHST4), ELISA Kit - MBS7217034 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Carbohyde sulfotransferase 4 (CHST4), ELISA Kit - MBS7250081 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Carbohyde sulfotransferase 4 (CHST4), ELISA Kit - MBS7238585 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Carbohyde sulfotransferase 4 (CHST4), ELISA Kit - MBS7209164 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Carbohyde sulfotransferase 4 (CHST4), ELISA Kit - MBS7253209 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Carbohyde sulfotransferase 4 (CHST4), ELISA Kit - MBS7228635 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Carbohyde sulfotransferase 4 (CHST4), ELISA Kit - MBS7243995 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Carbohyde sulfotransferase 4 (CHST4), ELISA Kit - MBS7201765 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Carbohyde sulfotransferase 4 (CHST4), ELISA Kit - MBS7240444 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Carbohydrate sulfotransferase 4, ELISA Kit - MBS283169 from MyBioSource

Category ELISA Kit
Prices $425.00, $720.00, $3,160.00, $6,055.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Carbohydrate Sulfotransferase 4 (CHST4), ELISA Kit - MBS9303522 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Custom Human CHST4 ELISA - ELH-CHST4 from RayBiotech

Category ELISA Kit
Prices $615.00, $1,107.00, $2,460.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human CHST4 Elisa kit - orb305224 from Biorbyt

Category ELISA Kit
Prices $1,148.00, $1,981.00, $4,284.00
Sizes 96 assays, 192 assays, 480 assays

Human CHST4 ELISA - RAB1368 from Sigma-Aldrich

Prices $615.00
Sizes 1 kt

Human CHST4/GST-3 ELISA - ELH-CHST4-1 from RayBiotech

Category ELISA Kit
Prices $457.00, $822.60, $1,828.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human CHST4 ELISA Kit - E006416 from Biobool

Category ELISA Kit

anti-GST3 / GST pi antibody - ARG55372 from Arigo Biolaboratories

Category ELISA Kit

anti-GST3 / GST pi antibody - ARG63784 from Arigo Biolaboratories

Category ELISA Kit
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