DLG1

Gene Symbol DLG1
Entrez Gene 1739
Alt Symbol DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg
Species Human
Gene Type protein-coding
Description discs, large homolog 1 (Drosophila)
Other Description disks large homolog 1|presynaptic protein SAP97|synapse-associated protein 97
Swissprots B9EIQ5 B7ZMM0 B4DGZ8 Q12959 E7EWL7 A5YKK7 B4DGU1 Q12958 D3DXB9 E9PG21 D3DXB8
Accessions CCQ43249 EAW53610 EAW53611 EAW53612 EAW53613 EAW53614 Q12959 AA837080 AB209536 BAD92773 AI223994 AK293967 BAG57339 AK294772 BAG57902 AK294855 BAG57959 AK304280 BAG65140 AK310596 AK310893 AK311129 AL831922 CAD38582 BC015560 AAH15560 BC028486 BC042118 BC140841 AAI40842 BC144651 AAI44652 BM728664 EF553524 ABQ66269 U13896 AAA50598 U13897 AAA50599 XM_005269289 XP_005269346 XM_005269301 XP_005269358 XM_011512493 XP_011510795 XM_011512494 XP_011510796 XM_011512495 XP_011510797 XM_011512496 XP_011510798 XM_011512497 XP_011510799 XM_011512498 XP_011510800 XM_011512499 XP_011510801 XM_011512500 XP_011510802 XM_011512501 XP_011510803 XM_011512502 XP_011510804 XM_011512503 XP_011510805 XM_011512504 XP_011510806 XM_011512505 XP_011510807 XM_011512506 XP_011510808 XM_011512507 XP_011510809 XM_011512508 XP_011510810 XM_011512509 XP_011510811 XR_246039 XR_924108 NM_001098424 NP_001091894 NM_001204386 NP_001191315 NM_001204387 NP_001191316 NM_001204388 NP_001191317 NM_001290983 NP_001277912 NM_004087 NP_004078
Function Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. {ECO:0000250, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917}.
Subcellular Location Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Basolateral cell membrane {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse. Cell membrane, sarcolemma. Note=Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity). {ECO:0000250}.
Tissue Specificity Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles. {ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:7937897}.
Top Pathways T cell receptor signaling pathway, HTLV-I infection, Viral carcinogenesis, Hippo signaling pathway

Human SAP97 peptide - ab101385 from Abcam

Category Peptide

Human SAP97 protein fragment - ab152336 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE analysis of ab152336 stained with Coomassie Blue.

SAP97 peptide - ab5852 from Abcam

Category Peptide

DLG1 / SAP97 Antibody Blocking Peptide - LS-E26448 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human DLG1 Protein - H00001739-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

SAP97 blocking peptide - GTX88739-PEP from GeneTex

Category Peptide
Prices $239.00
Sizes 100 μg
Species Human, Mouse, Rat

SAP97 Peptide - AC21-1287-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

DLG1 - H00001739-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

DLG1 - H00001739-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

DLG1 Control Peptide - SP5123CP from Acris Antibodies

Category Peptide
Prices $205.00
Sizes 50 µg

DLG1 Peptide - 46-831P from ProSci

Category Peptide
Species Human

Recombinant Human Disks large homolog 1(DLG1) ,partial - CSB-YP614264HU CSB-EP614264HU CSB-BP614264HU CSB-MP614264HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

DLG1, Peptide - MBS425482 from MyBioSource

Category Peptide
Prices $175.00
Sizes 100 µg
Species Human, Mouse, Rat

DLG1-Blocking-Peptide-Center - BP21841c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

DLG1 Peptide, Human - M34GP04337H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

DLG1 Immunizing peptide - orb50439 from Biorbyt

Category Peptide
Prices $247.00
Sizes 100 μg

Disks large homolog 1 (DLG1), partial, Recombinant Protein - MBS1427186 from MyBioSource

Category Protein
Prices $1,105.00, $1,105.00, $1,265.00, $1,265.00, $1,690.00, $1,690.00, $2,150.00, $2,150.00, $2,180.00, $3,330.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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