| Gene Symbol |
Vav3
|
| Entrez Gene |
57257
|
| Alt Symbol |
A530094I06Rik, AA986410, Idd18.1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
vav 3 oncogene
|
| Other Description |
VAV-3|guanine nucleotide exchange factor VAV3
|
| Swissprots |
Q9R0C8 Q7TS85 Q8R076 Q8CCF5 A2CFD7 Q8BRV2 Q9JLS6
|
| Accessions |
EDL01995 EDL01996 Q9R0C8 AF067816 AAF09171 AF140280 AAF20330 AK033253 BAC28212 AK041249 BAC30879 AK147053 BAE27637 AK150727 AK157057 BC027242 AAH27242 BC052739 AAH52739 XM_006501819 XP_006501882 XM_006501820 XP_006501883 XM_006535364 XP_006535427 XM_006535365 XP_006535428 NM_020505 NP_065251 NM_146139 NP_666251
|
| Function |
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not af
|
| Tissue Specificity |
Abundantly expressed in osteoclasts and mature osteoblasts. Also expressed in bone marrow macrophages (at protein level):.
|
| Top Pathways |
Focal adhesion, Leukocyte transendothelial migration, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, B cell receptor signaling pathway
|