FXN

Gene Symbol	FXN
Entrez Gene	2395
Alt Symbol	CyaY, FA, FARR, FRDA, X25
Species	Human
Gene Type	protein-coding
Description	frataxin
Other Description	Friedreich ataxia protein\|frataxin, mitochondrial
Swissprots	Q15294 O15545 C9JJ89 Q5VZ01 A8MXJ6 O95656 Q16595
Accessions	AAA98508 AAA98509 AAB84047 AAD00734 AAD00735 AAD00736 AAD49778 CAA74077 EAW62473 EAW62474 Q16595 AA232366 AI951739 AK308620 BC023633 AAH23633 BC048097 AAH48097 BF058880 HQ447980 ADQ32463 U43747 AAA98510 NM_000144 NP_000135 NM_001161706 NP_001155178 NM_181425 NP_852090
Function	Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1. {ECO:0000269\|PubMed:12785837, ECO:0000269\|PubMed:15247478, ECO:0000269\|PubMed:15641778, ECO:0000269\|PubMed:16239244, ECO:0000269\|PubMed:16608849, ECO:0000269\|PubMed:20053667}.
Subcellular Location	Cytoplasm. Mitochondrion. Note=PubMed:18725397 reports localization exclusively in mitochondria.
Tissue Specificity	Expressed in the heart, peripheral blood lymphocytes and dermal fibroblasts. {ECO:0000269\|PubMed:17468497}.
Top Pathways	Porphyrin and chlorophyll metabolism

Frataxin (H-155) - sc-25820 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Frataxin (H-155): sc-25820. Western blot analysis of Frataxin expression in rat brain tissue extract.

Frataxin (C-15) - sc-25108 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Frataxin (N-19) - sc-25106 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Frataxin (V-21) - sc-130757 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

Frataxin (V-21): sc-130757. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung carcinoma tissue showing cytoplasmic localization.

Anti-Frataxin antibody - ab175402 from Abcam

Prices	$384.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat kidney tissue labelling Frataxin with ab175402 at 1/100. Magnification: 200x.

Anti-Frataxin antibody - ab79858 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with ab79858 at a 1/50 dilution, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

Anti-Frataxin antibody - ab55021 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Western blot against tagged recombinant protein immunogen using ab55021 Frataxin antibody at 1ug/ml.

Anti-Frataxin antibody [18A5DB1] - ab110328 from Abcam

Prices	$400.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	18A5DB1

Anti-Frataxin antibody [18A5DB1] (ab110328) at 5 µg/ml + Recombinant Human Frataxin at 0.0005 µg

Anti-Frataxin antibody [18A5DB1] (Alexa Fluor® 488) - ab156033 from Abcam

Prices	$431.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	18A5DB1

Flow cytometric analysis of Human lymphocytes labeling Frataxin with ab156033 at 0.2 µg/ml. Lymphocytes were isolated from Control Patients (red), Freidrich Ataxia Carrier Patients (blue), and Friedrich Ataxia Patients (yellow). IgG1 Alexa®488 conjugated Isotype control antibody (black at 0.2 µg/ml).

Anti-Frataxin antibody [EPR6107] - ab124680 from Abcam

Prices	$378.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR6107

All lanes : Anti-Frataxin antibody [EPR6107] (ab124680) at 1/1000 dilutionLane 1 : Human heart lysateLane 2 : Human fetal skin lysateLane 3 : PBL lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-Frataxin antibody - N-terminal - ab156253 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Frataxin antibody - N-terminal (ab156253) at 1/100 dilution + SK-BR-3 cell line lysate at 35 µg

Anti-FXN / Frataxin Antibody - LS-C6889 from LifeSpan Bioscience

Prices	$605.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal

Anti-FXN / Frataxin Antibody (C-Terminus) - LS-C6890 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FXN / Frataxin Antibody (C-Terminus) - LS-C6891 from LifeSpan Bioscience

Prices	$385.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-FXN / Frataxin Antibody (Internal, clone EPR6107) - LS-C138783 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR6107

Western blot analysis on (A) human heart, (B) fetal skin, and (C) PBL lysates using anti-Frataxin antibody.

Anti-FXN / Frataxin Antibody (aa80-129) - LS-C145220 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

FXN / Frataxin antibody LS-C145220 Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.

Anti-FXN / Frataxin Antibody - LS-C331670 from LifeSpan Bioscience

Prices	$255.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of paraffin-embedded rat kidney using FXN antibody at dilution of 1:100 (200x lens).

Anti-FXN / Frataxin Antibody (clone 1C12) - LS-C173723 from LifeSpan Bioscience

Prices	$350.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1C12

IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-FXN mouse monoclonal antibody.

Anti-FXN / Frataxin Antibody (aa36-64) - LS-C157755 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

FXN Antibody western blot of SK-BR-3 cell line lysates (35 ug/lane). The FXN antibody detected the FXN protein (arrow).

Anti-FXN / Frataxin Antibody (clone 3C7) - LS-C173766 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3C7

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FXN (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FXN.

Anti-FXN / Frataxin Antibody (clone 3F3) - LS-C173768 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3F3

Anti-FXN / Frataxin Antibody (aa36-64, AP) - LS-C214399 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FXN / Frataxin Antibody (aa36-64, APC) - LS-C214400 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FXN / Frataxin Antibody (aa36-64, FITC) - LS-C214401 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FXN / Frataxin Antibody (aa36-64, Biotin) - LS-C214402 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Search more