FXN

Gene Symbol FXN
Entrez Gene 2395
Alt Symbol CyaY, FA, FARR, FRDA, X25
Species Human
Gene Type protein-coding
Description frataxin
Other Description Friedreich ataxia protein|frataxin, mitochondrial
Swissprots Q15294 O15545 C9JJ89 Q5VZ01 A8MXJ6 O95656 Q16595
Accessions AAA98508 AAA98509 AAB84047 AAD00734 AAD00735 AAD00736 AAD49778 CAA74077 EAW62473 EAW62474 Q16595 AA232366 AI951739 AK308620 BC023633 AAH23633 BC048097 AAH48097 BF058880 HQ447980 ADQ32463 U43747 AAA98510 NM_000144 NP_000135 NM_001161706 NP_001155178 NM_181425 NP_852090
Function Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1. {ECO:0000269|PubMed:12785837, ECO:0000269|PubMed:15247478, ECO:0000269|PubMed:15641778, ECO:0000269|PubMed:16239244, ECO:0000269|PubMed:16608849, ECO:0000269|PubMed:20053667}.
Subcellular Location Cytoplasm. Mitochondrion. Note=PubMed:18725397 reports localization exclusively in mitochondria.
Tissue Specificity Expressed in the heart, peripheral blood lymphocytes and dermal fibroblasts. {ECO:0000269|PubMed:17468497}.
Top Pathways Porphyrin and chlorophyll metabolism

FXN-Over-expression-Lysate - LY10362a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag FXN (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FXN gene (Lane 2, Cat. #LY10362a).

FXN 293T Cell Transient Overexpression Lysate(Denatured) - H00002395-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

FXN overexpression lysate - LY400054 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

FXN overexpression lysate - LY431136 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

FXN 293 Cell Lysate - 400148 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Frataxin Overexpression Lysate (Denatured) - H00002395-T01 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl
Species Human
FXN transfected lysate

Frataxin Overexpression Lysate (Native) - NBL1-10871 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Frataxin Overexpression Lysate (Adult Normal) [NBL1-10871] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Frataxin.

FXN Over-expression Lysate Product - GWB-D4DE5D from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human FXN Knockdown Stable Cell Line - CSC-DC005970 from Creative biogene

Category Cell Line
Species Human
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