ANO1

Gene Symbol ANO1
Entrez Gene 55107
Alt Symbol DOG1, ORAOV2, TAOS2, TMEM16A
Species Human
Gene Type protein-coding
Description anoctamin 1, calcium activated chloride channel
Other Description Ca2+-activated Cl- channel|anoctamin-1|discovered on gastrointestinal stromal tumors protein 1|oral cancer overexpressed 2|transmembrane protein 16A (eight membrane-spanning domains)|tumor-amplified and overexpressed sequence 2
Swissprots Q5XXA6 Q8IYY8 A8KAM3 Q8N7V3
Accessions EAW74757 EAW74758 EAW74759 Q5XXA6 AB845669 BAO49755 AI694083 AK001123 BAA91513 AK097619 BAC05123 AK293088 BAF85777 AK303971 BAH14087 AL833582 AY728143 AAU82085 BC027590 AAH27590 BC033036 AAH33036 CF593428 DB445158 DB450993 HQ418153 ADP09411 XM_006718602 XP_006718665 XM_006718604 XP_006718667 XM_006718605 XP_006718668 XM_011545121 XP_011543423 XM_011545122 XP_011543424 XM_011545123 XP_011543425 XM_011545124 XP_011543426 XM_011545125 XP_011543427 XM_011545126 XP_011543428 XM_011545127 XP_011543429 XM_011545128 XP_011543430 XM_011545129 XP_011543431 XM_011545130 XP_011543432 XM_011545131 XP_011543433 NM_018043 NP_060513 NR_030691
Function Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21984732, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors.
Tissue Specificity Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles. {ECO:0000269|PubMed:15215166, ECO:0000269|PubMed:16906560}.

TMEM16A CRISPR/Cas9 KO Plasmid (h) - sc-401314 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TMEM16A HDR Plasmid (h) - sc-401314-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TMEM16A Double Nickase Plasmid (h) - sc-401314-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TMEM16A Double Nickase Plasmid (h2) - sc-401314-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TMEM16A CRISPR Activation Plasmid (h) - sc-401314-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TMEM16A CRISPR Activation Plasmid (h2) - sc-401314-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TMEM16A Lentiviral Activation Particles (h) - sc-401314-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TMEM16A Lentiviral Activation Particles (h2) - sc-401314-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TMEM16A siRNA (h) - sc-76686 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TMEM16A shRNA Plasmid (h) - sc-76686-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TMEM16A shRNA (h) Lentiviral Particles - sc-76686-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU140771 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3240 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3240 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09927 from Sigma-Aldrich

Category miRNA

ANO1 siRNA (Human) - CRJ0472 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ANO1 - MBS8202109 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ANO1 (NM_018043.5) - SHH237290 from Creative biogene

Category siRNA
Species Reactivities Human

Human ANO1 siRNA - orb270973 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ANO1 shRNA Plasmid (Human) - CHJ0472 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ANO1 miRNA 3'UTR clone - MiUTR3H-11034 from Creative biogene

Species Reactivities Human
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