Htr1a

Gene Symbol Htr1a
Entrez Gene 15550
Alt Symbol Gpcr18
Species Mouse
Gene Type protein-coding
Description 5-hydroxytryptamine (serotonin) receptor 1A
Other Description 5-HT-1A|5-HT1A receptor|5-hydroxytryptamine receptor 1A|G-protein coupled receptor 18|serotonin receptor 1A
Swissprots Q61617 Q64264 Q8BGS4 Q60956
Accessions AAC52572 AAK50428 EDL18479 Q64264 AK034017 BAC28548 AK043668 BAC31611 AK049814 BAC33931 AK049884 BAC33970 AK140194 BAE24273 BC138669 AAI38670 BC138681 AAI38682 BY239730 BY601671 L20339 AAA16850 U39391 AAA81519 NM_008308 NP_032334
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:11080
Subcellular Location Cell membrane {ECO:0000269|PubMed:8254366}; Multi-pass membrane protein {ECO:0000269|PubMed:8254366}.
Tissue Specificity Most abundantly expressed in midbrain, in dorsal raphe and hippocampus. Detected at lower levels in amygdala and brain cortex. {ECO:0000269|PubMed:9826725}.
Top Pathways cAMP signaling pathway, Neuroactive ligand-receptor interaction

Mouse HTR1A ORF clone(NM_008308.4) - CDCH386369 from Creative Biomart

Species Mouse
Accession NM_008308.4

Mouse Htr1a ORF Clone(NM_008308.4) - CDCR245250 from Creative Biomart

Species Mouse
Accession NM_008308.4

Mouse Htr1a ORF Clone(NM_008308.4) - CDCR245251 from Creative Biomart

Species Mouse
Accession NM_008308.4

Mouse Htr1a ORF Clone(NM_008308.4) - CDCR245250 from Creative biogene

Species Mouse
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