| Gene Symbol | Htr1a |
|---|---|
| Entrez Gene | 15550 |
| Alt Symbol | Gpcr18 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | 5-hydroxytryptamine (serotonin) receptor 1A |
| Other Description | 5-HT-1A|5-HT1A receptor|5-hydroxytryptamine receptor 1A|G-protein coupled receptor 18|serotonin receptor 1A |
| Swissprots | Q61617 Q64264 Q8BGS4 Q60956 |
| Accessions | AAC52572 AAK50428 EDL18479 Q64264 AK034017 BAC28548 AK043668 BAC31611 AK049814 BAC33931 AK049884 BAC33970 AK140194 BAE24273 BC138669 AAI38670 BC138681 AAI38682 BY239730 BY601671 L20339 AAA16850 U39391 AAA81519 NM_008308 NP_032334 |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:11080 |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:8254366}; Multi-pass membrane protein {ECO:0000269|PubMed:8254366}. |
| Tissue Specificity | Most abundantly expressed in midbrain, in dorsal raphe and hippocampus. Detected at lower levels in amygdala and brain cortex. {ECO:0000269|PubMed:9826725}. |
| Top Pathways | cAMP signaling pathway, Neuroactive ligand-receptor interaction |
SR-1A CRISPR/Cas9 KO Plasmid (m) - sc-420989 from Santa Cruz Biotechnology
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SR-1A HDR Plasmid (m) - sc-420989-HDR from Santa Cruz Biotechnology
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SR-1A Double Nickase Plasmid (m) - sc-420989-NIC from Santa Cruz Biotechnology
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SR-1A Double Nickase Plasmid (m2) - sc-420989-NIC-2 from Santa Cruz Biotechnology
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SR-1A CRISPR Activation Plasmid (m) - sc-420989-ACT from Santa Cruz Biotechnology
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SR-1A CRISPR Activation Plasmid (m2) - sc-420989-ACT-2 from Santa Cruz Biotechnology
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SR-1A Lentiviral Activation Particles (m) - sc-420989-LAC from Santa Cruz Biotechnology
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SR-1A Lentiviral Activation Particles (m2) - sc-420989-LAC-2 from Santa Cruz Biotechnology
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SR-1A siRNA (m) - sc-36554 from Santa Cruz Biotechnology
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SR-1A shRNA Plasmid (m) - sc-36554-SH from Santa Cruz Biotechnology
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SR-1A shRNA (m) Lentiviral Particles - sc-36554-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN33544 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33544 from Sigma-Aldrich
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HTR1A siRNA (Mouse) - CRM1958 from Cohesion Biosciences
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HTR1A - MBS8227247 from MyBioSource
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shRNA set against Mouse HTR1A (NM_008308.4) - SHH315865 from Creative biogene
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shRNA set against Mouse Htr1a(NM_008308.4) - SHH135425 from Creative biogene
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HTR1A shRNA Plasmid (Mouse) - CHM1958 from Cohesion Biosciences
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HTR1A miRNA 3'UTR clone - MiUTR1M-05842 from Creative biogene
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