HSD17B6

Gene Symbol HSD17B6
Entrez Gene 8630
Alt Symbol HSE, RODH, SDR9C6
Species Human
Gene Type protein-coding
Description hydroxysteroid (17-beta) dehydrogenase 6
Other Description 17-beta-HSD 6|17-beta-hydroxysteroid dehydrogenase type 6|3(alpha->beta)-hydroxysteroid epimerase|3(alpha->beta)-hydroxysteroid epimerasel|3-alpha->beta-HSE|3-alpha->beta-hydroxysteroid epimerase|3-hydroxysteroid epimerase|NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase|hydroxysteroid (17-beta) dehydrogenase 6 homolog|oxidative 3-alpha hydroxysteroid dehydrogenase|oxidative 3-alpha-hydroxysteroid-dehydrogenase|oxidoreductase|retinol dehydrogenase|short chain dehydrogenase/reductase family 9C member 6|short chain dehydrogenase/reductase family 9C, member 6
Swissprots O43275 O14756
Accessions EAW96963 EAW96964 EAW96965 EAW96966 O14756 AA934892 AF016509 AAB67236 AF223225 AAF81017 AI760144 AK313423 BAG36215 BC020710 AAH20710 DA086202 HQ447624 ADQ32110 U89281 AAB88252 XM_005269207 XP_005269264 XM_005269208 XP_005269265 XM_005269209 XP_005269266 XM_006719672 XP_006719735 XM_011538925 XP_011537227 XM_011538926 XP_011537228 XM_011538927 XP_011537229 XR_245961 NM_003725 NP_003716
Function NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha- androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. {ECO:0000269|PubMed:10896656, ECO:0000269|PubMed:11360992, ECO:0000269|PubMed:11513953}.
Subcellular Location Microsome membrane {ECO:0000269|PubMed:11360992}; Peripheral membrane protein {ECO:0000269|PubMed:11360992}; Lumenal side {ECO:0000269|PubMed:11360992}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Lumenal side {ECO:0000305}.
Tissue Specificity Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain. {ECO:0000269|PubMed:10896656, ECO:0000269|PubMed:9188497}.
Top Pathways Steroid hormone biosynthesis, Retinol metabolism

HSD17B6-Over-expression-Lysate - LY15974a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag HSD17B6 (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the HSD17B6 gene‘

HSD17B6 293T Cell Transient Overexpression Lysate(Denatured) - H00008630-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

HSD17B6 293 Cell Lysate - 408619 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Species Mouse

HSD17B6 Overexpression Lysate (Native) - NBL1-11729 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: HSD17B6 Overexpression Lysate (Adult Normal) [NBL1-11729] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HSD17B6.

HSD17B6 Over-expression Lysate Product - GWB-8D5B77 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

HSD17B6 Overexpression Lysate (Denatured) - H00008630-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human HSD17B6 Knockdown Stable Cell Line - CSC-DC007283 from Creative biogene

Category Cell Line
Species Human
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