Gene Symbol | HSD17B6 |
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Entrez Gene | 8630 |
Alt Symbol | HSE, RODH, SDR9C6 |
Species | Human |
Gene Type | protein-coding |
Description | hydroxysteroid (17-beta) dehydrogenase 6 |
Other Description | 17-beta-HSD 6|17-beta-hydroxysteroid dehydrogenase type 6|3(alpha->beta)-hydroxysteroid epimerase|3(alpha->beta)-hydroxysteroid epimerasel|3-alpha->beta-HSE|3-alpha->beta-hydroxysteroid epimerase|3-hydroxysteroid epimerase|NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase|hydroxysteroid (17-beta) dehydrogenase 6 homolog|oxidative 3-alpha hydroxysteroid dehydrogenase|oxidative 3-alpha-hydroxysteroid-dehydrogenase|oxidoreductase|retinol dehydrogenase|short chain dehydrogenase/reductase family 9C member 6|short chain dehydrogenase/reductase family 9C, member 6 |
Swissprots | O43275 O14756 |
Accessions | EAW96963 EAW96964 EAW96965 EAW96966 O14756 AA934892 AF016509 AAB67236 AF223225 AAF81017 AI760144 AK313423 BAG36215 BC020710 AAH20710 DA086202 HQ447624 ADQ32110 U89281 AAB88252 XM_005269207 XP_005269264 XM_005269208 XP_005269265 XM_005269209 XP_005269266 XM_006719672 XP_006719735 XM_011538925 XP_011537227 XM_011538926 XP_011537228 XM_011538927 XP_011537229 XR_245961 NM_003725 NP_003716 |
Function | NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha- androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. {ECO:0000269|PubMed:10896656, ECO:0000269|PubMed:11360992, ECO:0000269|PubMed:11513953}. |
Subcellular Location | Microsome membrane {ECO:0000269|PubMed:11360992}; Peripheral membrane protein {ECO:0000269|PubMed:11360992}; Lumenal side {ECO:0000269|PubMed:11360992}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Lumenal side {ECO:0000305}. |
Tissue Specificity | Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain. {ECO:0000269|PubMed:10896656, ECO:0000269|PubMed:9188497}. |
Top Pathways | Steroid hormone biosynthesis, Retinol metabolism |
HSD17B6 peptide - ab156928 from Abcam
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Human HSD17B6 full length protein - ab152898 from Abcam
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Human HSD17B6 protein fragment - ab152899 from Abcam
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HSD17B6 Antibody Blocking Peptide - LS-E15288 from LifeSpan Bioscience
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Recombinant Human HSD17B6 Protein - H00008630-P01 from Novus Biologicals
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Recombinant Human HSD17B6 Protein - H00008630-Q01 from Novus Biologicals
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HSD17B6 Blocking Peptide - 33R-6617 from Fitzgerald
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17-beta HSD6 / HSD17B6 - H00008630-P01-10 from Acris Antibodies
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17-beta HSD6 / HSD17B6 - H00008630-P01-25 from Acris Antibodies
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17-beta HSD6 / HSD17B6 - H00008630-Q01-10 from Acris Antibodies
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17-beta HSD6 / HSD17B6 - H00008630-Q01-25 from Acris Antibodies
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HSD17B6 fusion protein - Ag2427 from Proteintech Group
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HSD17B6 fusion protein - ag17330 from Proteintech Group
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Recombinant Urate Oxidase - BP000741-ENZ-312 from Syd Labs
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Recombinant Human HSD17B6, GST-tagged - HSD17B6-13961H from Creative Biomart
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Oxidoreductase - PPT-53363 from Nordic BioSite
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Recombinant Human 17-beta-hydroxysteroid dehydrogenase type 6(HSD17B6) - CSB-YP010775HU CSB-EP010775HU CSB-BP010775HU CSB-MP010775HU from Cusabio
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17-beta-hydroxysteroid dehydrogenase type 6 (HSD17B6), Recombinant Protein - MBS1173484 from MyBioSource
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17-beta HSD6 / HSD17B6 - TP304701 from Acris Antibodies
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HSD17B6 Recombinant Protein Antigen - NBP2-32431PEP from Novus Biologicals
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HSD17B6-Antibody-N-term-Blocking-Peptide - BP9516a from Abgent, a WuXi AppTec company
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HSD17B6 Peptide, Human - M34GP07283H from Creative Peptides
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