VAMP7

Gene Symbol VAMP7
Entrez Gene 6845
Alt Symbol SYBL1, TI-VAMP, TIVAMP, VAMP-7
Species Human
Gene Type protein-coding
Description vesicle-associated membrane protein 7
Other Description synaptobrevin-like 1|synaptobrevin-like protein 1|tetanus neurotoxin-insensitive VAMP|tetanus-insensitive VAMP
Swissprots Q9H4A7 Q53GY7 Q7Z409 P51809
Accessions CAB96816 EAW55877 EAW55878 EAW55879 EAW55880 EAW55881 EAW55882 EAW55883 P51809 AI042181 AI522002 AJ295938 CAC16891 AJ549301 CAD70593 AK222794 BAD96514 AK293525 BAG57007 AK295605 BAG58491 AK297385 BAG59826 AK312658 BAG35541 AM393132 CAL38010 BC056141 AAH56141 DC341378 X92396 CAA63133 XM_011531188 XP_011529490 XM_011545653 XP_011543955 NM_001145149 NP_001138621 NM_001185183 NP_001172112 NM_005638 NP_005629 NR_033714 NR_033715
Function Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. {ECO:0000269|PubMed:10888671, ECO:0000269|PubMed:16677249, ECO:0000269|PubMed:18042464}.
Subcellular Location Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Single-pass type IV membrane protein {ECO:0000269|PubMed:17897319}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or k
Tissue Specificity Detected in all tissues tested.
Top Pathways SNARE interactions in vesicular transport

VAMP7 (D8Y1R) Rabbit mAb (IF Specific) - 13876 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (200 tests)
Host Rabbit
Clonality Monoclonal
Clone D8Y1R
Confocal immunofluorescent analysis of A172 cells using VAMP7 (D8Y1R) Rabbit mAb (IF Specific) (green). Actin filaments were labeled with DyLight™ 554 Phalloidin #13054 (red). Blue pseudocolor = DRAQ5 ® #4084 (fluorescent DNA dye).

VAMP7 (D4D5J) Rabbit mAb - 14811 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4D5J
Western blot analysis of extracts from various cell lines using VAMP7 (D4D5J) Rabbit mAb.

VAMP7 Antibody - 13920 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human VAMP7 protein (hVAMP7-Myc/DDK; +), using VAMP7 Antibody (upper) or Myc-Tag (71D10) Rabbit mAb #2278 (lower).

TI-VAMP (E-12) - sc-166394 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TI-VAMP (E-12): sc-166394. Western blot analysis of TI-VAMP expression in HeLa (A) and ES-2 (B) whole cell lysates.

TI-VAMP (H-55) - sc-67060 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TI-VAMP (H-55): sc-67060. Western blot analysis of TI-VAMP expression in HeLa (A) and PC-12 (B) whole cell lysates and rat brain tissue extract (C).

TI-VAMP (N-20) - sc-32592 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TI-VAMP (D-17) - sc-32593 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SYBL1 antibody - ab68834 from Abcam

Host Rabbit
Clonality Polyclonal
ICC/IF image of ab68834 stained HeLa cells. The cells were 4% PFA fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab68834, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-SYBL1 antibody - ab68776 from Abcam

Host Rabbit
Clonality Polyclonal
ab68776 (1/2000) staining SYBL1 in 1-day-old mouse cortical cells. DAPI counterstained

Anti-SYBL1 antibody - ab84089 from Abcam

Host Sheep
Clonality Polyclonal

Anti-SYBL1 antibody - ab56188 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SYBL1 antibody - ab116463 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SYBL1 antibody (ab116463) at 1/100 dilution + A2058 cell line lysates at 35 µg

Anti-SYBL1 antibody [158.2] - ab36195 from Abcam

Prices $385.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 158.2
Anti-SYBL1 antibody [158.2] (ab36195) at 1/500 dilution + Tissue lysates prepared from rat brain

Anti-VAMP7 / SYBL1 / T1 VAMP Antibody (N-Terminus) - LS-C47080 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VAMP7 / SYBL1 / T1 VAMP Antibody (aa50-100) - LS-C94812 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-VAMP7 / SYBL1 / T1 VAMP Antibody (clone 158.2) - LS-C144542 from LifeSpan Bioscience

Prices $365.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 158.2

Anti-VAMP7 / SYBL1 / T1 VAMP Antibody (clone 158.2) - LS-C153345 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 158.2

Anti-VAMP7 / SYBL1 / T1 VAMP Antibody (aa50-80, AP) - LS-C273237 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VAMP7 / SYBL1 / T1 VAMP Antibody (aa50-80, APC) - LS-C273238 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VAMP7 / SYBL1 / T1 VAMP Antibody (aa50-80, Biotin) - LS-C273239 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VAMP7 / SYBL1 / T1 VAMP Antibody (aa50-80, FITC) - LS-C273240 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VAMP7 / SYBL1 / T1 VAMP Antibody (aa50-80, Azide-free, HRP) - LS-C273241 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VAMP7 / SYBL1 / T1 VAMP Antibody (aa50-80, PE) - LS-C273242 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VAMP7 / SYBL1 / T1 VAMP Antibody - LS-C285636 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VAMP7 / SYBL1 / T1 VAMP Antibody (clone 158.2) IHC-plus™ - LS-B7494 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 158.2
Anti-VAMP7 / SYBL1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7494 concentration 10 ug/ml.
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