VAMP7

Gene Symbol	VAMP7
Entrez Gene	6845
Alt Symbol	SYBL1, TI-VAMP, TIVAMP, VAMP-7
Species	Human
Gene Type	protein-coding
Description	vesicle-associated membrane protein 7
Other Description	synaptobrevin-like 1|synaptobrevin-like protein 1|tetanus neurotoxin-insensitive VAMP|tetanus-insensitive VAMP
Swissprots	Q9H4A7 Q53GY7 Q7Z409 P51809
Accessions	CAB96816 EAW55877 EAW55878 EAW55879 EAW55880 EAW55881 EAW55882 EAW55883 P51809 AI042181 AI522002 AJ295938 CAC16891 AJ549301 CAD70593 AK222794 BAD96514 AK293525 BAG57007 AK295605 BAG58491 AK297385 BAG59826 AK312658 BAG35541 AM393132 CAL38010 BC056141 AAH56141 DC341378 X92396 CAA63133 XM_011531188 XP_011529490 XM_011545653 XP_011543955 NM_001145149 NP_001138621 NM_001185183 NP_001172112 NM_005638 NP_005629 NR_033714 NR_033715
Function	Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. {ECO:0000269|PubMed:10888671, ECO:0000269|PubMed:16677249, ECO:0000269|PubMed:18042464}.
Subcellular Location	Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Single-pass type IV membrane protein {ECO:0000269|PubMed:17897319}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or k
Tissue Specificity	Detected in all tissues tested.
Top Pathways	SNARE interactions in vesicular transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SYBL1 full length protein - ab132421 from Abcam Category Protein Source Wheat germ Species Human

Human SYBL1 protein fragment - ab131706 from Abcam Category Protein Source E. coli Species Human

SYBL1 peptide (113-125) - ab45744 from Abcam Category Peptide Species Human

VAMP7 / SYBL1 / T1 VAMP Antibody Blocking Peptide - LS-E2768 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VAMP7 / SYBL1 / T1 VAMP Antibody Blocking Peptide - LS-E31296 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

VAMP7 / SYBL1 / T1 VAMP Antibody Blocking Peptide - LS-E17252 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VAMP-7 Recombinant Protein - H00006845-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

VAMP-7 Partial Recombinant Protein - H00006845-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

VAMP-7 Protein - NBP2-22939 from Novus Biologicals Category Protein Species Human

VAMP7-Antibody-Center-Blocking-peptide - BP13865c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

VAMP7 blocking peptide - GTX89534-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Human VAMP7 protein - orb169535 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

VAMP7 Blocking Peptide - 33R-4443 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

VAMP7 protein (His tag) - 80R-2430 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

VAMP-7 / SYBL1 (1-188, His-tag) - AR50510PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

VAMP-7 / SYBL1 (1-188, His-tag) - AR50510PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

VAMP-7 / SYBL1 - H00006845-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

VAMP-7 / SYBL1 - H00006845-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

VAMP-7 / SYBL1 - H00006845-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

VAMP-7 / SYBL1 - H00006845-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

VAMP-7 / SYBL1 Control Peptide - AP55441CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

VAMP7, 1-188aa, Human, His tag, E.coli - 01-P1686 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

VAMP7 Peptide - 6929P from ProSci Category Peptide Species Human

VAMP7 Human - PRPS-1201 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source E.coli. Species Human

VAMP7, 1-188aa, Recombinant Protein - GWB-P0352A from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

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