HLA-DQA2

Gene Symbol	HLA-DQA2
Entrez Gene	3118
Alt Symbol	DX-ALPHA, HLA-DXA
Species	Human
Gene Type	protein-coding
Description	major histocompatibility complex, class II, DQ alpha 2
Other Description	DX alpha chain|HLA class II histocompatibility antigen, DQ alpha 2 chain|HLA class II histocompatibility antigen, DQ(6) alpha chain|MHC class II DQA2
Swissprots	O19789 Q5SR04 B0V0E7 Q5SQ94 A2BF37 P01906
Accessions	AAA35772 AAA36249 AAA59605 AAA59761 AAA59834 AAD14077 AFA43495 AKE47356 CAA25142 CAB06493 CEL26596 P01906 M95727 M95728 NM_020056 NP_064440
Function	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa
Subcellular Location	Cell membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Lysosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Tissue Specificity	Restricted to skin Langerhans cells, although some expression at low levels may occur at the surface of B lymphoblastoid cells. {ECO:0000269|PubMed:22407913, ECO:0000269|PubMed:9036956}.
Top Pathways	Inflammatory bowel disease (IBD), HTLV-I infection, Influenza A, Tuberculosis, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HLA-DQA1/2 (N-20) - sc-17960 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-HLA-DQA2 antibody - ab136667 from Abcam Prices $407.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-HLA-DQA2 antibody - ab156404 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 antibody - ab105759 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 antibody - ab105760 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 antibody - ab111120 from Abcam Prices $370.00 Sizes 200 µl Host Goat Clonality Polyclonal

Anti-HLA-DQA2 Antibody (aa39-66) - LS-C157813 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 Antibody (aa40-50) IHC-plus™ - LS-B7406 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-HLA-DQA2 Antibody (aa39-66, APC) - LS-C215103 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 Antibody (aa39-66, AP) - LS-C215102 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 Antibody (aa39-66, Biotin) - LS-C215104 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 Antibody (aa39-66, FITC) - LS-C215105 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 Antibody (aa39-66, Azide-free, HRP) - LS-C215106 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 Antibody - LS-C285741 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 Antibody (Biotin) - LS-C316735 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 Antibody (aa39-66, PE) - LS-C215108 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 Antibody (HRP) - LS-C316740 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 Antibody (FITC) - LS-C316737 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 Antibody (aa39-66) - LS-C321995 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 Antibody (aa241-251) - LS-C139656 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-HLA-DQA2 Antibody (aa35-84) - LS-C116373 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-HLA-DQA2 Antibody (aa71-120) - LS-C116374 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

HLA DQA2 Antibody - NBP1-89687 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

HLA DQA2 Antibody - NBP1-52094 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Goat Clonality Polyclonal

HLA DQA2 Antibody - NBP1-52186 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Goat Clonality Polyclonal

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