HLA-DQA2

Gene Symbol	HLA-DQA2
Entrez Gene	3118
Alt Symbol	DX-ALPHA, HLA-DXA
Species	Human
Gene Type	protein-coding
Description	major histocompatibility complex, class II, DQ alpha 2
Other Description	DX alpha chain|HLA class II histocompatibility antigen, DQ alpha 2 chain|HLA class II histocompatibility antigen, DQ(6) alpha chain|MHC class II DQA2
Swissprots	O19789 Q5SR04 B0V0E7 Q5SQ94 A2BF37 P01906
Accessions	AAA35772 AAA36249 AAA59605 AAA59761 AAA59834 AAD14077 AFA43495 AKE47356 CAA25142 CAB06493 CEL26596 P01906 M95727 M95728 NM_020056 NP_064440
Function	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa
Subcellular Location	Cell membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Lysosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Tissue Specificity	Restricted to skin Langerhans cells, although some expression at low levels may occur at the surface of B lymphoblastoid cells. {ECO:0000269|PubMed:22407913, ECO:0000269|PubMed:9036956}.
Top Pathways	Inflammatory bowel disease (IBD), HTLV-I infection, Influenza A, Tuberculosis, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HLA-DQA2 Antibody Blocking Peptide - LS-E27499 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HLA-DQA2 Antibody Blocking Peptide - LS-E27498 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HLA-DQA2 Antibody Blocking Peptide - LS-E17854 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HLA-DQA2 Antibody Blocking Peptide - LS-E17853 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant human HLA class II histocompatibility antigen, DQ alpha 2 chain (OPCA01050) - OPCA01050 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human HLA-DQA2 protein - orb245606 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

HLA-DQA2 Blocking Peptide - 33R-3648 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HLA-DQA2 Blocking Peptide - 33R-5275 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HLA-DQA2 Peptide - AC21-2321-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

HLA-DQA2 Peptide - AC21-2322-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

HLA-DQA2 Peptide - 42-668P from ProSci Category Peptide Species Human

HLA-DQA2 Peptide - 42-669P from ProSci Category Peptide

Recombinant human HLA class II histocompatibility antigen, DQ alpha 2 chain - CSB-EP148294h CSB-BP148294h CSB-MP148294h from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human HLA class II histocompatibility antigen, DQ alpha 2 chain(HLA-DQA2),partial - CSB-RP148294h from Cusabio Category Protein Source E.coli Species Human

Recombinant Human HLA class II histocompatibility antigen, DQ alpha 2 chain(HLA-DQA2) - CSB-YP010493HU CSB-EP010493HU CSB-BP010493HU CSB-MP010493HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

HLA class II histocompatibility antigen, DQ alpha 2 chain - RPC140679 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

HLA-DQA2, Peptide - MBS427447 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

HLA-DQA2 & HLA-DQA1, Peptide - MBS428250 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

HLA DQA2 Protein - NBP1-89687PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

HLA-DQA2-Blocking-Peptide-Center - BP20203c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HLA-DQA2 Peptide, Human - M34GP07094H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant human HLA class II histocompatibility antigen, DQ alpha 2 chain - AP72270 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

HLA class II histocompatibility antigen, DQ alpha 2, Recombinant Protein - MBS1265426 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $1,180.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli) Source E Coli

HLA class II histocompatibility antigen, DQ alpha 2 chain, Recombinant Protein - MBS7042851 from MyBioSource Category Protein Prices $1,050.00, $2,035.00, $3,240.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

HLA class II histocompatibility antigen, DQ alpha 2 chain, Recombinant Protein - MBS9422022 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

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