ASIP

Gene Symbol ASIP
Entrez Gene 434
Alt Symbol AGSW, AGTI, AGTIL, ASP, SHEP9
Species Human
Gene Type protein-coding
Description agouti signaling protein
Other Description agouti signaling protein, nonagouti homolog|agouti switch protein|agouti-signaling protein|nonagouti homolog
Swissprots P42127 Q3SXL2
Accessions AAA89208 AAB61247 EAW76282 P42127 AY805393 BC104238 AAI04239 BC104239 AAI04240 XM_005260412 XP_005260469 XM_011528820 XP_011527122 XM_011528821 XP_011527123 XM_011528822 XP_011527124 XM_011528823 XP_011527125 NM_001672 NP_001663
Function Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Subcellular Location Secreted.
Tissue Specificity Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and foreskin.
Top Pathways Melanogenesis

ASP (S-21) - sc-18626 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ASP (C-19) - sc-18627 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ASIP antibody - ab151033 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human rectum tissue labeling ASIP with ab151033 antibody at 1/1000.

Anti-ASIP Antibody (C-Terminus) - LS-C34920 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal

Anti-ASIP Antibody (N-Terminus) - LS-C34915 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ASIP Antibody (N-Terminus) - LS-C34916 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-ASIP Antibody (aa1-40) - LS-C183744 from LifeSpan Bioscience

Prices $605.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-ASIP Antibody (aa1-40) - LS-C183745 from LifeSpan Bioscience

Prices $605.00
Sizes 400 µg
Host Rabbit
Clonality Polyclonal

Anti-ASIP Antibody - LS-C346374 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of HeLa cell using ASIP antibody. Blue: DAPI for nuclear staining.

ASIP Antibody - NBP2-14323 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: ASIP Antibody [NBP2-14323] - Staining of human cell line CACO-2 shows localization to vesicles.

Anti-ASIP antibody produced in rabbit - HPA048636 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ASIP:<B>Cat. No. HPA048636</B>: Immunohistochemical staining of human rectum shows moderate cytoplasmic positivity in glandular cells.

Anti-ASIP (56-70) antibody produced in rabbit - SAB1100893 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-ASIP (56-70) : <B>Cat. No. SAB1100893</B>: Immunofluorescence of HUVEC cells using ASIP (56-70) , Cat. No. SAB1100893 (red) at a 1:400 dilution, taken at 40x magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

A1CF antibody, N-term - GTX47219 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-A1CF antibody, N-term used in Western blot. GTX47219

A1CF antibody, N-term - GTX47318 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-A1CF antibody, N-term used in Western blot. GTX47318

ASIP antibody [EP310Y], C-term - GTX61321 from GeneTex

Host Rabbit
Clonality Monoclonal
Clone EP310Y
Anti-ASIP antibody [EP310Y], C-term used in Western blot. GTX61321

C3a desArg antibody - 10-1804 from Fitzgerald

Prices $475.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone M81625

C3a desArg antibody - 10-1805 from Fitzgerald

Prices $475.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone M81611

C3a desArg antibody (biotin) - 61-1027 from Fitzgerald

Prices $725.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone M81611-B

ASPA antibody - 70R-3333 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Aspartoacylase antibody - 70R-13532 from Fitzgerald

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ASIP Polyclonal Antibody - A6872 from ABclonal

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human prostate cancer using ASIP antibody at dilution of 1:100 (40x lens).

ASIP Antibody - abx005235 from Abbexa

Host Rabbit
Clonality Polyclonal
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