| Gene Symbol |
ASIP
|
| Entrez Gene |
434
|
| Alt Symbol |
AGSW, AGTI, AGTIL, ASP, SHEP9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
agouti signaling protein
|
| Other Description |
agouti signaling protein, nonagouti homolog|agouti switch protein|agouti-signaling protein|nonagouti homolog
|
| Swissprots |
P42127 Q3SXL2
|
| Accessions |
AAA89208 AAB61247 EAW76282 P42127 AY805393 BC104238 AAI04239 BC104239 AAI04240 XM_005260412 XP_005260469 XM_011528820 XP_011527122 XM_011528821 XP_011527123 XM_011528822 XP_011527124 XM_011528823 XP_011527125 NM_001672 NP_001663
|
| Function |
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and foreskin.
|
| Top Pathways |
Melanogenesis
|