FADS2

Gene Symbol	FADS2
Entrez Gene	9415
Alt Symbol	D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13
Species	Human
Gene Type	protein-coding
Description	fatty acid desaturase 2
Other Description	delta(6) desaturase|delta(6) fatty acid desaturase|delta-6 desaturase|delta-6 fatty acid desaturase|delta-6-desaturase|linoleoyl-CoA desaturase (delta-6-desaturase)-like 2
Swissprots	A8K2M6 Q9H3G3 O95864 B7Z634 Q6MZQ7 Q96SV8 Q96H07 Q9Y3X4
Accessions	CAF86135 EAW73974 EAW73975 O95864 AA665550 AF084559 AAG23121 AF108658 AAG43192 AF126799 AAD20018 AK027459 BAG51327 AK027513 BAB55167 AK027577 BAG51351 AK074925 BAG52031 AK074939 BAC11305 AK074991 AK123240 BAG53882 AK290291 BAF82980 AK299762 BAH13120 AL050118 CAB43280 BC009011 AAH09011 DA233832 HY090295 XM_011545395 XP_011543697 NM_001281501 NP_001268430 NM_001281502 NP_001268431 NM_004265 NP_004256
Function	Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum. {ECO:0000269|PubMed:12713571, ECO:0000269|PubMed:9867867}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues; lowest levels were found in patients with poor prognostic index. {ECO:0000269|PubMed:10860662, ECO:0000269|PubMed:12851727, ECO:0000269|PubMed:9867867}.
Top Pathways	PPAR signaling pathway, alpha-Linolenic acid metabolism, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FADS2 full length protein - ab132816 from Abcam Category Protein Source Wheat germ Species Human

Human FADS2 peptide - ab90992 from Abcam Category Peptide

Human FADS2 protein fragment - ab160481 from Abcam Category Protein Source Wheat germ Species Human

Delta-6 Desaturase / FADS2 Antibody Blocking Peptide - LS-E1556 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Fatty acid desaturase 2 Protein - H00009415-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Fatty acid desaturase 2 Protein - H00009415-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FADS2-Antibody-N-term-Blocking-peptide - BP12296a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FADS2 - H00009415-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FADS2 - H00009415-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FADS2 - H00009415-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FADS2 - H00009415-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FADS2-Specific fusion protein - ag3447 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Fatty Acid Desaturase 2 (FADS2) - RPF417Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Fatty Acid Desaturase 2 (FADS2) - RPF417Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Fatty Acid Desaturase 2 (FADS2) - RPF417Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Fatty Acid Desaturase 2 Protein (Recombinant) - abx167027 from Abbexa Category Protein Source Human Species Human

FADS2 - TP323780 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Homo sapiens (Human) Fatty acid desaturase 2 - CSB-EP007960HU from Cusabio Category Protein Source E.coli Species Human

Fatty acid desaturase 2 Recombinant Protein Antigen - NBP1-84311PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FADS2-Blocking-Peptide-Center - BP5368c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FADS2 Peptide, Human - M34GP05196H from Creative Peptides Category Peptide Source Synthetic. Species Human

FADS2 Recombinant Protein (OPCA03513) - OPCA03513 from Aviva Systems Biology Category Protein Prices $285.00 Sizes 50 µg Source Human

Fatty acid desaturase 2, Recombinant Protein - MBS7042705 from MyBioSource Category Protein Prices $1,245.00, $2,235.00, $3,440.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Fatty acid desaturase 2, Recombinant Protein - MBS1090546 from MyBioSource Category Protein Prices $145.00, $205.00, $520.00, $850.00, $870.00, $1,095.00, $1,095.00, $1,245.00, $1,340.00, $1,690.00, $1,690.00 Sizes 10 µg (E-Coli), 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 100 µg (Baculovirus), 1 mg (E-Coli), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Fatty acid desaturase 2 (FADS2), Recombinant Protein - MBS7014489 from MyBioSource Category Protein Prices $1,245.00, $2,235.00, $3,440.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Orangutan

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