MAPK7

Gene Symbol	MAPK7
Entrez Gene	5598
Alt Symbol	BMK1, ERK4, ERK5, PRKM7
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 7
Other Description	BMK-1|BMK1 kinase|ERK-5|MAP kinase 7|MAPK 7|big MAP kinase 1|extracellular signal-regulated kinase 5|extracellular-signal-regulated kinase 5
Swissprots	Q6QLU7 Q59F50 Q7L4P4 Q96G51 Q16634 Q969G1 Q13164
Accessions	AAA82933 EAW50883 EAW50884 EAW50885 EAW50886 EAW50887 Q13164 AB209611 BAD92848 AK295376 BAG58335 AY534741 AAS38577 BC007404 AAH07404 BC007992 AAH07992 BC009963 AAH09963 BC030134 AAH30134 BP871947 DA452383 DB133227 HQ257997 ADR82751 U25278 AAA81381 U29725 AAA82931 U29726 AAA82932 XM_005256719 XP_005256776 XM_006721557 XP_006721620 XM_006721558 XP_006721621 XM_006721559 XP_006721622 XM_011523957 XP_011522259 NM_002749 NP_002740 NM_139032 NP_620601 NM_139033 NP_620602 NM_139034 NP_620603
Function	Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.
Subcellular Location	Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation.
Tissue Specificity	Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver. {ECO:0000269|PubMed:7759517}.
Top Pathways	Gap junction, GnRH signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ERK5 full length protein - ab126913 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human ERK5 full length protein - ab152635 from Abcam Category Protein Source Wheat germ Species Human

Human ERK5 protein fragment - ab114671 from Abcam Category Protein Source Wheat germ Species Human

MAPK7 / ERK5 Antibody Blocking Peptide - LS-E21087 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK7 / ERK5 Antibody Blocking Peptide - LS-E9011 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ERK5/BMK1 Protein - H00005598-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human ERK5/BMK1 Protein - H00005598-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ERK5/BMK1 Peptide - P2504 from Novus Biologicals Category Peptide Species Human

MAPK7-Antibody-C-term-Blocking-peptide - BP7504a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAPK7 - H00005598-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

MAPK7 - P5548 from Acris Antibodies Category Protein Prices $790.00 Sizes 5 µg Species Human

MAPK7 - P5672 from Acris Antibodies Category Protein Prices $1,180.00 Sizes 50 µg Species Human

MAPK7 - P5680 from Acris Antibodies Category Protein Prices $1,180.00 Sizes 50 µg Species Human

MAPK7 / ERK5 - H00005598-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAPK7 / ERK5 - H00005598-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAPK7 fusion protein - ag0017 from Proteintech Group Category Protein Source E. coli-derived, Species Human

MAPK7 fusion protein - ag1648 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human MAPK7 - MAPK7-26231TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Mitogen-Activated Protein Kinase 7, GST-Tagged - MAPK7-1050H from Creative Biomart Category Protein Species Human

Recombinant Mitogen Activated Protein Kinase 7 (MAPK7) - RPB431Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Mitogen Activated Protein Kinase 7 (MAPK7) - RPB431Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Mitogen Activated Protein Kinase 7 (MAPK7) - RPB431Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Mitogen-activated protein kinase 7(MAPK7) ,partial - CSB-YP013465HU CSB-EP013465HU CSB-BP013465HU CSB-MP013465HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MAPK7 / ERK5 (transcript variant 3) - TP303506 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Phospho-MAPK7T218-Antibody-Blocking-peptide - BP3610a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

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