MAPK7

Gene Symbol	MAPK7
Entrez Gene	5598
Alt Symbol	BMK1, ERK4, ERK5, PRKM7
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 7
Other Description	BMK-1|BMK1 kinase|ERK-5|MAP kinase 7|MAPK 7|big MAP kinase 1|extracellular signal-regulated kinase 5|extracellular-signal-regulated kinase 5
Swissprots	Q6QLU7 Q59F50 Q7L4P4 Q96G51 Q16634 Q969G1 Q13164
Accessions	AAA82933 EAW50883 EAW50884 EAW50885 EAW50886 EAW50887 Q13164 AB209611 BAD92848 AK295376 BAG58335 AY534741 AAS38577 BC007404 AAH07404 BC007992 AAH07992 BC009963 AAH09963 BC030134 AAH30134 BP871947 DA452383 DB133227 HQ257997 ADR82751 U25278 AAA81381 U29725 AAA82931 U29726 AAA82932 XM_005256719 XP_005256776 XM_006721557 XP_006721620 XM_006721558 XP_006721621 XM_006721559 XP_006721622 XM_011523957 XP_011522259 NM_002749 NP_002740 NM_139032 NP_620601 NM_139033 NP_620602 NM_139034 NP_620603
Function	Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.
Subcellular Location	Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation.
Tissue Specificity	Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver. {ECO:0000269|PubMed:7759517}.
Top Pathways	Gap junction, GnRH signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® ERK5 siRNA I - 7301 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

ERK 5 CRISPR/Cas9 KO Plasmid (h) - sc-400891 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 5 HDR Plasmid (h) - sc-400891-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 5 Double Nickase Plasmid (h) - sc-400891-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 5 Double Nickase Plasmid (h2) - sc-400891-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 5 CRISPR Activation Plasmid (h) - sc-400891-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 5 CRISPR Activation Plasmid (h2) - sc-400891-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 5 Lentiviral Activation Particles (h) - sc-400891-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 5 Lentiviral Activation Particles (h2) - sc-400891-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 5 siRNA (h) - sc-35339 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 5 shRNA Plasmid (h) - sc-35339-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 5 shRNA (h) Lentiviral Particles - sc-35339-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK5/BMK1 RNAi - H00005598-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ERK5/BMK1 RNAi - H00005598-R08 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU133471 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1217 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1216 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1218 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN13015 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13015 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02585 from Sigma-Aldrich Category miRNA

MAPK7 siRNA (Human) - CRH3768 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ERK5/BMK1 RNAi - H00005598-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ERK5/BMK1 RNAi - H00005598-R07 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human MAPK7 (NM_002749.3) - SHH338063 from Creative biogene Category siRNA Species Reactivities Human

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